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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |  |
Net income | $ 185,959 | $ 128,291 | $ 59,926
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Inventory step-up charges | 0 | 2,130 | 734
Depreciation and amortization | 50,985 | 38,447 | 27,067
Amortization of debt discount and issuance costs | 1,815 | 11,530 | 10,970
Stock-based compensation expense | 27,316 | 27,500 | 17,007
Contingent consideration expense | (28,729) | 5,865 | 0
Deferred income taxes, net | (1,352) | 6,517 | (3,992)
Other | (100) | 864 | 267
Changes in operating assets and liabilities, excluding impact of acquisitions: |  |  |
Accounts receivable | (3,596) | (46,523) | (20,892)
Inventories | (57,204) | (89,781) | (29,994)
Prepaid expenses and other assets | 2,396 | (10,192) | (4,870)
Operating lease right of use assets | (24,549) | (4,315) | 3,583
Other assets | (231) | 430 | 175
Accounts payable | (8,197) | 19,523 | 2,462
Accrued expenses | (2,019) | 23,196 | 1,037
Operating lease liability | 28,623 | 6,958 | (1,964)
Long-term liabilities | 966 | (1,424) | 1,109
Total cash provided by operating activities | 172,083 | 119,016 | 62,625
Cash flows from investing activities: |  |  |
Purchase of marketable securities held to maturity | (100,000) | 0 | 0
Additions to capitalized software costs | (3,512) | (4,187) | (3,889)
Acquisitions, net of cash acquired | 0 | (149,893) | (175,041)
Purchases of property, plant and equipment | (84,834) | (67,089) | (22,455)
Purchase of intellectual property | (45,000) | 0 | 0
Other investing activities | 110 | 0 | 0
Total cash used in investing activities | (233,236) | (221,169) | (201,385)
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of issuance costs | 0 | 0 | 297,775
Proceeds from exercise of stock options | 3,707 | 3,879 | 8,151
Repayment of Convertible Senior Notes | (26) | (21) | 0
Payment of tax withholding obligation on vesting of restricted stock | (17,018) | (2,897) | (10)
Total cash (used in) provided by financing activities | (13,337) | 961 | 305,916
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (5,866) | (12,286) | 12,729
Net (decrease) increase in cash, cash equivalents and restricted cash | (80,356) | (113,478) | 179,885
Cash, cash equivalents and restricted cash, beginning of period | 603,814 | 717,292 | 537,407
Cash and cash equivalents, end of period | 523,458 | 603,814 | 717,292
Supplemental disclosure of cash flow information: |  |  |
Income taxes paid | 34,365 | 16,515 | 10,279
Interest paid | 1,033 | 1,066 | 1,066
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Assets acquired under operating leases | 29,126 | 85,312 | 3,349
ARTeSYN Biosolutions Holdings Ireland Limited |  |  |
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Fair value of earnouts related to acquisition | 0 | 0 | 69,422
Avitide, Inc. |  |  |
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Contingent consideration expense | 28,700 | 5,900 |
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Fair value of common stock issued for acquisition | 0 | 82,968 | 0
Fair value of earnouts related to acquisition | $ 0 | $ 94,238 | $ 0

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