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RESEARCH AND LICENSE AGREEMENTS WITH PRINCETON UNIVERSITY, UNIVERSITY OF SOUTHERN CALIFORNIA AND THE UNIVERSITY OF MICHIGAN (Details) - USD ($) |  | 12 Months Ended | 31 Months Ended | 36 Months Ended | 120 Months Ended
--- | --- | --- | --- | --- | ---
Jun. 01, 2013 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2015 | Apr. 30, 2009 | Jul. 31, 2007
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |
Royalty expense |  | $ 5,370,000 | $ 4,519,000 | $ 3,273,000 |  |  |
1997 Research Agreement [Member] |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |
Term of agreement (in years) |  |  |  |  |  |  | 10 years
2006 Research Agreement - Original Term [Member] |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |
Term of agreement (in years) |  |  |  |  |  | 3 years |
Research and development expense incurred |  |  |  |  |  | $ 5,000,000 |
2006 Research Agreement - Extended Term [Member] |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |
Term of agreement (in years) | 4 years |  |  |  |  |  |
Research and development expense incurred |  |  |  |  | $ 3,000,000 |  |
Maximum obligation |  | $ 3,500,000 |  |  | $ 3,500,000 |  |
1997 Amended License Agreement [Member] |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |
Royalty rate for licensed products sold by the Company (in hundredths) |  | 3.00% |  |  |  |  |
Royalty rate for licensed products sold by the Company's sublicenses (in hundredths) |  | 3.00% |  |  |  |  |
Minimum royalty payment per year |  | $ 100,000 |  |  |  |  |
Royalty expense |  | 5,400,000 | $ 4,500,000 | $ 3,200,000 |  |  |
Minimum investment per year |  | $ 800,000 |  |  |  |  |

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