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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net income (loss) $ 23,751 $ (10,457)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:    
Amortization of deferred revenue (3,601) (4,893)
Depreciation 1,839 1,439
Amortization of intangibles 5,579 5,500
Inventory write-down   33,000
Amortization of premium and discount on investments, net (801) (285)
Stock-based compensation to employees 5,401 4,039
Stock-based compensation to Board of Directors and Scientific Advisory Board 891 659
Deferred income tax benefit 4,826 3,984
Retirement plan benefit expense 1,982 1,512
Decrease (increase) in assets:    
Accounts receivable 6,745 4,697
Inventory (3,719) (12,860)
Other current assets (3,174) (417)
Other assets (369) 80
Increase (decrease) in liabilities:    
Accounts payable and accrued expenses (5,625) 826
Other current liabilities 256 (58)
Deferred revenue 2,250 48,412
Net cash provided by operating activities 36,231 75,178
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of property and equipment (2,162) (3,146)
Purchase of intangibles (96,033)  
Purchases of investments (325,226) (267,520)
Proceeds from sale of investments 364,017 263,058
Net cash used in investing activities (59,404) (7,608)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock 202 171
Proceeds from the exercise of common stock options 182 1,372
Payment of withholding taxes related to stock-based compensation to employees (4,794) (5,280)
Net cash used in financing activities (4,410) (3,737)
(DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS (27,583) 63,833
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD 97,513 45,418
CASH AND CASH EQUIVALENTS, END OF PERIOD $ 69,930 $ 109,251