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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
CASH FLOWS FROM OPERATING ACTIVITIES:      
Net income $ 48,070 $ 14,678 $ 41,854
Adjustments to reconcile net income to net cash provided by operating activities:      
Amortization of deferred revenue (7,406) (8,994) (4,274)
Depreciation 4,270 3,086 2,077
Amortization of intangibles 16,492 10,999 10,997
Inventory write-down   33,000 3,900
Amortization of premium and discount on investments, net (1,830) (697) (531)
Stock-based compensation to employees 11,374 9,173 7,278
Stock-based compensation to Board of Directors and Scientific Advisory Board 1,715 1,291 995
Deferred income tax benefit 3,094 7,137 9,108
Excess tax benefits from share-based payment arrangements (4,232)    
Retirement plan benefit expense 3,965 3,354 1,679
Decrease (increase) in assets, net of effect of acquisition:      
Accounts receivable 1,205 (2,654) (6,418)
Inventory (4,460) (8,639) (30,414)
Other current assets (3,870) 1,969 2,267
Other assets (133) 251 (183)
Increase (decrease) in liabilities, net of effect of acquisition:      
Accounts payable and accrued expenses 4,362 790 3,055
Other current liabilities 4,362 56 87
Deferred revenue 3,360 48,812 5,793
Net cash provided by operating activities 80,338 113,612 47,270
CASH FLOWS FROM INVESTING ACTIVITIES:      
Purchases of property and equipment (7,300) (5,103) (6,153)
Purchase of intangibles (95,989)    
Purchase of business, net of cash acquired (33,380)    
Purchases of investments (450,277) (691,876) (408,974)
Proceeds from sale of investments 548,474 638,411 372,818
Net cash used in investing activities (38,472) (58,568) (42,309)
CASH FLOWS FROM FINANCING ACTIVITIES:      
Proceeds from issuance of common stock 439 354 328
Repurchase of common stock     (29,500)
Proceeds from the exercise of common stock options 185 2,034 1,887
Payment of withholding taxes on stock-based compensation to employees (4,870) (5,337) (2,844)
Net cash used in financing activities (14) (2,949) (30,129)
Excess tax benefits from share-based payment arrangements 4,232    
INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS 41,852 52,095 (25,168)
CASH AND CASH EQUIVALENTS, BEGINNING OF YEAR 97,513 45,418 70,586
CASH AND CASH EQUIVALENTS, END OF YEAR 139,365 $ 97,513 $ 45,418
Earnout liability recorded for Adesis acquisition $ 1,670