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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
CASH FLOWS FROM OPERATING ACTIVITIES:      
Net income $ 103,885 $ 48,070 $ 14,678
Adjustments to reconcile net income to net cash provided by operating activities:      
Amortization of deferred revenue (11,122) (7,406) (8,994)
Depreciation 4,919 4,270 3,086
Amortization of intangibles 21,983 16,492 10,999
Inventory write-down     33,000
Amortization of premium and discount on investments, net (2,871) (1,830) (697)
Stock-based compensation to employees 12,284 11,374 9,173
Stock-based compensation to Board of Directors and Scientific Advisory Board 2,609 1,715 1,291
Change in earnout liability recorded for Adesis acquistion 519    
Deferred income tax expense 24,396 3,094 7,137
Excess tax benefits from share-based payment arrangements   (4,232)  
Retirement plan benefit expense 4,351 3,965 3,354
Decrease (increase) in assets, net of effect of acquisition:      
Accounts receivable (27,361) 1,205 (2,654)
Inventory (18,951) (4,460) (8,639)
Other current assets (3,884) (3,870) 1,969
Other assets (297) (133) 251
Increase (decrease) in liabilities:      
Accounts payable and accrued expenses 16,420 4,362 790
Other current liabilities (1,917) 4,362 56
Deferred revenue 8,402 3,360 48,812
Net cash provided by operating activities 133,365 80,338 113,612
CASH FLOWS FROM INVESTING ACTIVITIES:      
Purchases of property and equipment (29,803) (7,300) (5,103)
Purchase of intangibles   (95,989)  
Purchase of business, net of cash acquired   (33,380)  
Purchases of investments (594,283) (450,277) (691,876)
Proceeds from sale of investments 498,508 548,474 638,411
Net cash used in investing activities (125,578) (38,472) (58,568)
CASH FLOWS FROM FINANCING ACTIVITIES:      
Proceeds from issuance of common stock 734 439 354
Proceeds from the exercise of common stock options 38 185 2,034
Payment of withholding taxes on stock-based compensation to employees (9,432) (4,870) (5,337)
Excess tax benefits from share-based payment arrangements   4,232  
Cash dividends paid (5,652)    
Net cash used in financing activities (14,312) (14) (2,949)
INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS (6,525) 41,852 52,095
CASH AND CASH EQUIVALENTS, BEGINNING OF YEAR 139,365 97,513 45,418
CASH AND CASH EQUIVALENTS, END OF YEAR $ 132,840 $ 139,365 $ 97,513