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RESEARCH AND LICENSE AGREEMENTS WITH ACADEMIC PARTNERS- Additional Information (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Research And Development Arrangement Contract To Perform For Others [Line Items] |  |  |
Royalty expense | $ 691,000 | $ 11,125,000 | $ 11,776,000
1997 Amended License Agreement [Member] |  |  |
Research And Development Arrangement Contract To Perform For Others [Line Items] |  |  |
Royalty expense | $ 691,000 | 11,100,000 | 11,800,000
Royalty rate for licensed products sold by the Company (in hundredths) | 3.00% |  |
Royalty rate for licensed products sold by the Company's sublicenses (in hundredths) | 3.00% |  |
2006 Research Agreement [Member] |  |  |
Research And Development Arrangement Contract To Perform For Others [Line Items] |  |  |
Research agreement, extension term (in years) | 2 years |  |
Research agreement, new amendment expiration date | Apr. 30, 2023 |  |
Maximum obligation | $ 4,300,000 |  |
Research and development expense incurred | $ 1,300,000 | $ 1,200,000 | $ 997,000

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- Definition The maximum amount the Company is obligated to pay under the specified research agreement, as of the balance sheet date. + References No definition available. + Details
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- Definition The royalty rate of net sales price for licensed products sold by the Company, under the specified arrangement. + References No definition available. + Details
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- Definition The royalty rate of revenues received by the Company for licensed products sold by the Company's sublicenses, under the specified arrangement. + References No definition available. + Details
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- Definition The amount of costs incurred under a research and development arrangement accounted for as a contract to perform research and development for others. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 20 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6420387&loc=d3e23221-108380 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 20 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6420387&loc=d3e23199-108380 + Details
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