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RESEARCH AND LICENSE AGREEMENTS WITH ACADEMIC PARTNERS- Additional Information (Details) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Research And Development Arrangement Contract To Perform For Others [Line Items]      
Royalty expense $ 691,000 $ 11,125,000 $ 11,776,000
1997 Amended License Agreement [Member]      
Research And Development Arrangement Contract To Perform For Others [Line Items]      
Royalty expense $ 691,000 11,100,000 11,800,000
Royalty rate for licensed products sold by the Company (in hundredths) 3.00%    
Royalty rate for licensed products sold by the Company's sublicenses (in hundredths) 3.00%    
2006 Research Agreement [Member]      
Research And Development Arrangement Contract To Perform For Others [Line Items]      
Research agreement, extension term (in years) 2 years    
Research agreement, new amendment expiration date Apr. 30, 2023    
Maximum obligation $ 4,300,000    
Research and development expense incurred $ 1,300,000 $ 1,200,000 $ 997,000