STOCK-BASED COMPENSATION - Equity Instruments Other Than Options - Additional Information (Details) - USD ($)	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Fair value of shares withheld for tax withholding obligations	$ 14,949,000	$ 14,394,000	$ 15,980,000
Director [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock awards and units vesting terms	1 year
Fair value of shares issued	$ 1,200,000	$ 1,300,000	$ 916,000
Shares issued (in shares)	5,412	6,456	9,332
Restricted Stock Units (RSUs) [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average grant-date fair value of RSU awards granted (in dollars per share)	$ 208.67	$ 162.32	$ 168.95
Fair value as of the respective vesting dates	$ 15,100,000	$ 7,700,000	$ 7,700,000
Grants in period (shares)	116,024
Restricted Stock Units (RSUs) [Member] \| Research and Development Expense [Member] \| Non Employee Members of Scientific Advisory Board [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense	$ 220,000	$ 380,000	$ 632,000
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average grant-date fair value of RSU awards granted (in dollars per share)	$ 172.95	$ 155.85	$ 194.19
Fair value as of the respective vesting dates	$ 20,000,000.0	$ 24,500,000	$ 28,400,000
Shares withheld for employee taxes (shares)	69,798	86,442	86,075
Shares withheld for employee taxes	$ 14,100,000	$ 12,500,000	$ 14,000,000.0
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized	$ 35,500,000
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition	2 years 3 months 3 days
Grants in period (shares)	30,647
Unrecognized compensation expense related to performance unit awards	$ 35,500,000
Restricted Stock [Member] \| Selling, General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense	15,400,000	13,900,000	10,000,000.0
Restricted Stock [Member] \| Manufacturing Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense	2,500,000	1,900,000	1,100,000
Restricted Stock [Member] \| Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense	$ 5,200,000	$ 4,300,000	$ 2,500,000
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average grant-date fair value of RSU awards granted (in dollars per share)	$ 214.70	$ 167.74	$ 198.72
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized	$ 21,400,000
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition	1 year 11 months 8 days
Grants in period (shares)	74,074
Shares withheld for tax withholding obligations (in shares)	3,881	12,877	16,668
Fair value of shares withheld for tax withholding obligations	$ 875,000	$ 1,900,000	$ 2,600,000
Unrecognized compensation expense related to performance unit awards	$ 21,400,000
Performance Shares [Member] \| Incremental Performance Based [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants in period (shares)	77,086	95,772	10,096
Performance Shares [Member] \| Performance-Based Vesting Requirement [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants in period (shares)	42,291	47,885	5,050
Performance Shares [Member] \| Market-Based Vesting Requirement [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants in period (shares)	34,795	47,887	5,046
Performance Shares [Member] \| Company Performance-Based Vesting Requirement [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants in period (shares)	0	15,638	15,650
Performance Shares [Member] \| Selling, General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense	$ 8,000,000.0	$ 4,300,000	$ 1,700,000
Performance Shares [Member] \| Manufacturing Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense	1,300,000	670,000	208,000
Performance Shares [Member] \| Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense	$ 2,100,000	$ 1,100,000	$ 419,000

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