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CONSOLIDATED STATEMENTS OF CASH FLOWS Non-Cash Activities - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Other Significant Noncash Transactions [Line Items]      
Unrealized (loss) gain on available-for-sale securities $ (295) $ (118) $ 241
Net change in accounts payable and accrued expenses related to purchases of property and equipment (3,526) (1,468) (530)
Cash paid for income tax 52,650 36,269 46,602
Common Stock Issued to Board of Directors and Scientific Advisory Board that was Earned and Accrued for in Previous Period [Member]      
Other Significant Noncash Transactions [Line Items]      
Other significant noncash transaction, value of consideration received $ 300 $ 300 $ 300