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Income Taxes - Deferred tax assets and liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
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Deferred tax assets: |  |
Net operating loss carryforwards | $ 153,685 | $ 135,470
Research and development credits | 16,139 | 14,380
Orphan drug credit | 25,484 | 19,281
Capitalized license fee | 2,311 | 2,776
Stock-based compensation | 13,159 | 11,074
Section 174 Costs | 50,688 | 29,663
Deferred revenue | 350 | 438
Accrued Expenses & Other | 5,680 | 4,536
Total deferred tax assets | 267,496 | 217,618
Valuation allowance | (267,158) | (217,257)
Net deferred tax assets | 338 | 361
Deferred tax liabilities: |  |
Operating lease right-of-use asset and other | (338) | (361)
Total deferred tax liabilities: | $ (338) | $ (361)

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