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Income Taxes - Operating loss carryforward (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022
Operating loss carryforwards |  |
Increase in valuation allowance | $ 49,901 | $ 59,046
Federal net operating loss carryforwards | 555,563 |
State net operating loss carryforwards | 597,952 |
Net operating loss indefinite carryforwards | 482,396 |
Foreign net operating loss carryforwards | 1,342 |
Federal orphan drug credit related to qualifying research | 25,484 |
Unremitted earnings of foreign subsidiaries | 730 |
Accrued interest or penalties related to uncertain tax positions | 0 | $ 0
Research tax credits | Federal |  |
Operating loss carryforwards |  |
Research tax credits | 13,142 |
Research tax credits | State |  |
Operating loss carryforwards |  |
Research tax credits | $ 3,794 |

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