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Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2023

Stock-based Compensation

Schedule of significant assumptions used to compute the fair values of employee and director stock options awarded

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​	​	​	​	​	​	​	​	​	​
​	​	Year ended
​	​	December 31,
​	​	2023		​	2022		​	2021
Risk‑free interest rate	​	2.35	%	​	2.19	%	​	0.79	%
Expected term (in years)	​	6.11	​	​	6.11	​	​	6.11	​
Expected volatility	​	76.11	%	​	69.16	%	​	69.80	%
Expected dividend yield	​	—	​	​	—	​	​	—	​

Summary of common stock option activity

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Weighted‑

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Weighted-

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Average

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Average

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Remaining

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Aggregate

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Number of

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Exercise

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Contractual

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Intrinsic

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Options

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Price

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​

Term

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​

Value

Outstanding as of December 31, 2022

6,374,544

​

$

17.85

​

​

7.73

​

$

73,994

Granted

​

​

1,053,888

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$

25.42

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—

​

$

—

Exercised

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​

(529,854)

​

$

14.09

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—

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$

9,225

Cancelled

​

​

(347,553)

​

$

21.23

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—

​

$

—

Outstanding as of December 31, 2023

6,551,025

​

$

19.19

​

​

7.23

​

$

175,419

Options exercisable at December 31, 2023

3,936,040

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$

19.77

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​

6.54

​

$

103,122

Summary of restricted stock unit activity

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​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​
​	​	​		​		​
​	​	​	​	​	​	Weighted-
​	​	​	​	​	​	Average
​	​	​	​	Number of	​	Grant Date
​	​	​	​	RSUs	​	Fair Value
Unvested as of December 31, 2022				774,166	​	$	12.18
Granted	​	​		643,028	​		24.97
Vested	​	​		(214,837)	​		14.30
Cancelled	​	​		(97,750)	​		15.61
Unvested as of December 31, 2023				1,104,607	​	$	17.44

Summary of performance stock unit activity

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​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​
​	​	​		​		​
​	​	​	​	​	​	Weighted-
​	​	​	​	​	​	Average
​	​	​	​	Number of	​	Grant Date
​	​	​	​	PSUs	​	Fair Value
Unvested as of December 31, 2022				804,797	​	$	13.24
Granted	​	​		—	​		—
Vested	​	​		—	​		—
Cancelled	​	​		(223,451)	​		13.24
Unvested as of December 31, 2023				581,346	​	$	13.24

Summary of stock-based compensation expense

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​	​	​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​	​	​
​	​	Year Ended
​	​	December 31,
​		2023		​	2022		​	2021
Research and development	​	$	8,449	​	$	5,814	​	$	7,687
Selling, general, and administrative	​		24,104	​		14,017	​		13,117
Total	​	$	32,553	​	$	19,831	​	$	20,804

Summary of stock-based compensation expense by award type

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​	​	​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​	​	​
​	​	Year Ended
​	​	December 31,
​		2023		​	2022		​	2021
Stock options	​	$	17,671	​	$	15,477	​	$	17,988
Employees stock purchase plan	​	​	581	​	​	408	​	​	310
Restricted stock units	​		5,998	​		2,918	​		1,924
Performance stock units	​	​	8,303	​	​	1,028	​	​	582
Total	​	$	32,553	​	$	19,831	​	$	20,804

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Tabular disclosure of share-based payment arrangement.

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Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Tabular disclosure of number and weighted-average grant date fair value for nonvested performance shares.

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