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Income Taxes - Operating loss carryforward (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Operating loss carryforwards    
Increase in valuation allowance $ 49,901 $ 59,046
Federal net operating loss carryforwards 555,563  
State net operating loss carryforwards 597,952  
Net operating loss indefinite carryforwards 482,396  
Foreign net operating loss carryforwards 1,342  
Federal orphan drug credit related to qualifying research 25,484  
Unremitted earnings of foreign subsidiaries 730  
Accrued interest or penalties related to uncertain tax positions 0 $ 0
Research tax credits | Federal    
Operating loss carryforwards    
Research tax credits 13,142  
Research tax credits | State    
Operating loss carryforwards    
Research tax credits $ 3,794