Off-balance sheet commitments given	12 Months Ended
Dec. 31, 2024
Off-Balance Sheet Commitments [Abstract]
Off-balance sheet commitments given	Off-balance sheet commitments givenNote 25.1. Commitments under collaboration, research, service provision and licensing agreements granted by the Group Collaboration, research and development, and licensing agreements, and licensing options related to the “Modulation of RNA biogenesis” platform. •Exclusive licensing agreement with the CNRS, the University of Montpellier and the Institut Curie On December 4, 2008, the French National Centre for Scientific Research (CNRS), the University of Montpellier and the Institut Curie granted the Group four exclusive licenses. These licenses cover the use of their technology and products by the Group in the field of human and veterinary health relating to the use of synthetic products modifying mRNA splicing, for research, diagnosis, prevention and treatment of any possible indication. The licensing agreement includes low single-digit royalties based on future net sales to be paid by the Group. •Research collaboration contract with the CNRS, the University of Montpellier and the Institut Curie Concomitantly with a research collaboration framework contract relating to the creation of a cooperative laboratory, ended in December 2021, the parties have signed a financial agreement defining the financial terms for the exploitation of patents. This contract was signed on 15 April 2009 for a duration of one year and was subsequently renewed up until March 31, 2022. •Research and development contract with license option with the CNRS, the University of Montpellier and Theradiag The CNRS, the University of Montpellier, the Group and Theradiag conducted since 2013 a collaborative project notably in the fields of HIV and HTLV-1 called CARENA, in connection with a funding obtained through Bpifrance. The overall project provided for co-ownership and cross-licenses on the project's results through various instruments. The Group met all obligations and the project was closed in December 2024. Exclusive licensing contract with “The Scripps Research Institute, University of Chicago and Brigham Young University” with the “Immune Stimulation” platform (ABX196 product) On 11 November 2006, The Scripps Research Institute (La Jolla, California, USA), in agreement with the University of Chicago (Chicago, Illinois, USA) and Brigham Young University (Provo, Utah, USA), granted the Group an exclusive license in the field of human and veterinary health on its technology and products relating to the use of iNKT agonists for research, diagnosis, prevention and treatment of all possible indications. In consideration for the licensing rights granted to it under the agreement, the Group had to: •pay The Scripps Research Institute milestones at different stages of clinical and regulatory development of the first product (the milestones amount to $50 thousand at IND filing, paid in September 2019 and capitalized, $300 thousand at Phase 3 and $500 thousand at IND approval) and low single-digit royalties for vaccines, diagnostic tests and therapeutic products, according to the amount of net sales, and •give The Scripps Research Institute, University of Chicago and Brigham Young University an equitable interest in the Group (as of the date of these financial statements, these three academic institutions hold 0.41% of the Group’s undiluted capital). During the year ended December 31, 2022, the Group made the decision to freeze the development program for ABX196 in the treatment of hepatocellular cancer (see Note 3.1 - Impairment of ABX196 cash-generating unit ). Subsequently, in 2024, the licensing contract was terminated. Note 25.2. Commitments under BPI conditional advances Bpifrance CARENA contract As part of the development of therapeutic and diagnostic solutions targeting alternative splicing and RNA interference in the fields of virology (HIV-AIDS, HTLV-1) and metabolism (obesity), SPLICOS (absorbed by the Group on 31 October 2014) has entered into a Master Support Agreement with Bpifrance as well as a conditional advance contract in the name of the “CARENA” Strategic Industrial Innovation Project dated December 16, 2013. The Group, acting as project leader for the CARENA project, was associated as part of a consortium contract with Theradiag, a Group specializing in in vitro diagnostics and the development of theranostic tests for monitoring biotherapies, as well as at the CNRS and the University of Montpellier. The CARENA project aimed to develop the anti-HIV-AIDS therapeutic program with the compound ABX464 up to the Phase 2b study, as well as a companion test set up by Theradiag simultaneously with the clinical development. Beyond the anti-HIV-AIDS program, the CARENA project could extend its pharmacological investigations to another retrovirus that could be combated by the same approach: HTLV-1. The Group is committed to reimbursing the received conditional advances up to €3,840 thousand. The Group will also have to pay an annuity of 50% of the proceeds from the sale of the intellectual property rights resulting from the project, as well as the sale of the prototypes, preproduction and models produced under the project; the sum due to Bpifrance under this provision will be deducted from the repayment of the conditional advances. In addition, if the advance is repaid under the conditions outlined above, the Group will pay to Bpifrance, over a period of five consecutive years after the date on which the repayment schedule ends and provided that the Group has reached cumulative pre-tax revenue greater than or equal to €50 million, an amount equal to 1.20% of the annual revenue generated from the sale of the products developed as part of the project. This supplementary payment amount is capped at €6,800 thousand. The total period, including fixed payments and incentive payments, is limited to 15 years. In June 2024, the Group and Bpifrance agreed to terminate the project due to technical failure. Termination became effective in December 2024 after the Group refunded €234 thousand corresponding to a portion of the funding received. The Group is therefore released of its obligations to pay an annuities on the proceeds from the sale of the intellectual property rights resulting from the project. Bpifrance RNP-VIR contract In pursuit of the CARENA project, focused on the clinical development of a drug molecule and demonstrating the validity of an innovative therapeutic approach targeting viral RNPs, the Group has entered into a Master Support Agreement with Bpifrance as well as a beneficiary agreement with conditional advance for the “RNP-VIR” structuring research and development project for competitiveness dated December 16, 2016. The RNP-VIR project aimed to further the discovery of new molecules for the treatment of multiple infectious diseases by the development of the antiviral technology platform. The Group, acting as project leader of the RNP-VIR project, was associated in a consortium contract with the CNRS and the University of Montpellier. The Group is committed to reimburse the received conditional advances up to €6,576 thousand. If applicable, the Group will also have to pay an annuity of 50% of the proceeds from the sale of the intellectual property rights resulting from the project, as well as the sale of the prototypes, preproduction and models produced under the project. The sum due to Bpifrance under this provision will be deducted from the last payment (and if needed from the previous payments). If the advance is repaid under the conditions outlined above, the Group will pay to Bpifrance, over a period of five consecutive years following the date on which the repayment schedule ends and provided that the Group has reached cumulative pre-tax revenue greater than or equal to €25 million, an amount equal to 3% of the annual revenue generated from the sale of products developed as part of the project. The supplementary payments amount is capped at €5,500 thousand. The total period, including fixed payments and incentive payments, is limited to 15 years. In June 2024, the Group and Bpifrance agreed to terminate the project due to technical failure. Termination became effective in December 2024. The Group is therefore released of its obligations to pay an annuities on the proceeds from the sale of the intellectual property rights resulting from the project. Bpifrance Ebola The Bpifrance and Occitanie Region joint support agreement granted on June 2, 2017 consists of conditional advances to the Group for a total amount of up to €390 thousand, based on the success of the program (respectively €130 thousand from the Languedoc Roussillon Midi Pyrénées Region and €260 thousand from Bpifrance). In September 2019, the Group decided to terminate this program, due to the existence of a vaccine in the process of being licensed for this indication as well as changes in the macroeconomic climate for public funding. The reimbursement of the conditional advance was spread until June 2024. Note 25.3. Pledge assets to Kreos, Claret and Heights As part of the KREOS 1 & 2 bonds, Kreos benefits from first-rate collateral on the Group’s principal tangible and intangible assets, including its commercial fund, intellectual property rights in its principal drug candidates, as well as a pledge of the Group’s bank accounts and claims. On August 21, 2023, the outstanding Kreos 1 & 2 bond loans were repaid in full, using the proceeds from the new Kreos / Claret Financing (see Note 3.3). The Kreos / Claret Financing provides for certain restrictive covenants (subject to customary exceptions) which include, among other things, restrictions on the incurrence of indebtedness, cross-default, the distribution of dividends and the grant of security interests, and which would cause the bonds to become repayable on demand in case of breach. As of December 31, 2024, the Group complied with these restrictive covenants. As security for the Kreos / Claret Financing, the lenders benefit from the grant of first-ranking collateral on the Group’s principal tangible and intangible assets, including pledges over the Group’s business (fonds de commerce) as a going concern and intellectual property rights in the Group's lead drug candidate, as well as pledges over the Group’s bank accounts and receivables. Such securities apply to all tranches of the Kreos / Claret Financing. The Heights Financing is a senior, unsecured financing. The terms and conditions of the Heights convertible notes include a standard negative pledge providing that any security granted in favor of other borrowed debt or debt instruments should also be granted in favor of the Heights convertible notes on an equal basis (with the exception of the securities issued pursuant to the Kreos / Claret Financing, as detailed above). Note 25.4. Other commitments related to research and partnership arrangements In the ordinary course of business, the Group regularly uses the services of subcontractors and enters into research and partnership arrangements with various contract research organizations, or CROs, and with public- sector partners or subcontractors, who conduct clinical trials and studies in relation to the drug candidates. At December 31, 2022, 2023, and 2024 the Group’s commitments amounted to €194,731 thousand, €201,777 thousand and €234,908 thousand. The cost of services performed by CROs is recognized as an operating expense as incurred. Note 25.5. Leases Following the end (in December 31, 2021) of the Framework agreement with CNRS (French National Centre for Scientific Research) and the University of Montpellier for research collaboration to create a cooperative laboratory, a hosting agreement was signed in 2022 with CNRS, so that the Group can continue its research program at the CNRS center for the year 2023, and was subsequently renewed for 2024 and 2025. In December 2022, following the end of the Research collaboration contract with the CNRS, the University of Montpellier and the Institut Curie, the Company and the Institut Curie concluded a new contract for a duration of one year, renewable by amendment, granting the Company access to some of the Institute’s equipment and consumables. The contract was subsequently renewed for 2024 and 2025, under similar conditions. The above agreements fall within the scope of the short-term lease exemption of IFRS 16, and the related rental expenses are therefore recognized in operating expenses as incurred. The Group's commitments in relation to other ongoing leases are set forth in Note 15.8 and 15.13. Note 25.6. Litigation related to Prosynergia acquisition On December 12, 2024, the Group was notified of a claim from the seller of Prosynergia requesting the payment of an earn-out in connection with the transaction. Legal proceedings are ongoing in French court. The Group has not recorded any provision in its financial statements in connection with this claim due to uncertainty in the outcome of this proceeding.

Off-balance sheet commitments given

12 Months Ended

Dec. 31, 2024

Off-Balance Sheet Commitments [Abstract]

Off-balance sheet commitments givenNote 25.1. Commitments under collaboration, research, service provision and licensing agreements granted by the Group

Collaboration, research and development, and licensing agreements, and licensing options related to the “Modulation of RNA

biogenesis” platform.

•Exclusive licensing agreement with the CNRS, the University of Montpellier and the Institut Curie

On December 4, 2008, the French National Centre for Scientific Research (CNRS), the University of Montpellier and

the Institut Curie granted the Group four exclusive licenses. These licenses cover the use of their technology and

products by the Group in the field of human and veterinary health relating to the use of synthetic products modifying

mRNA splicing, for research, diagnosis, prevention and treatment of any possible indication. The licensing agreement

includes low single-digit royalties based on future net sales to be paid by the Group.

•Research collaboration contract with the CNRS, the University of Montpellier and the Institut Curie

Concomitantly with a research collaboration framework contract relating to the creation of a cooperative laboratory,

ended in December 2021, the parties have signed a financial agreement defining the financial terms for the exploitation

of patents. This contract was signed on 15 April 2009 for a duration of one year and was subsequently renewed up until

March 31, 2022.

•Research and development contract with license option with the CNRS, the University of Montpellier and Theradiag

The CNRS, the University of Montpellier, the Group and Theradiag conducted since 2013 a collaborative project

notably in the fields of HIV and HTLV-1 called CARENA, in connection with a funding obtained through Bpifrance.

The overall project provided for co-ownership and cross-licenses on the project's results through various instruments.

The Group met all obligations and the project was closed in December 2024.

Exclusive licensing contract with “The Scripps Research Institute, University of Chicago and Brigham Young University” with the

“Immune Stimulation” platform (ABX196 product)

On 11 November 2006, The Scripps Research Institute (La Jolla, California, USA), in agreement with the University of Chicago

(Chicago, Illinois, USA) and Brigham Young University (Provo, Utah, USA), granted the Group an exclusive license in the field of

human and veterinary health on its technology and products relating to the use of iNKT agonists for research, diagnosis, prevention

and treatment of all possible indications. In consideration for the licensing rights granted to it under the agreement, the Group had to:

•pay The Scripps Research Institute milestones at different stages of clinical and regulatory development of the first

product (the milestones amount to $50 thousand at IND filing, paid in September 2019 and capitalized, $300 thousand at

Phase 3 and $500 thousand at IND approval) and low single-digit royalties for vaccines, diagnostic tests and therapeutic

products, according to the amount of net sales, and

•give The Scripps Research Institute, University of Chicago and Brigham Young University an equitable interest in the

Group (as of the date of these financial statements, these three academic institutions hold 0.41% of the Group’s

undiluted capital).

During the year ended December 31, 2022, the Group made the decision to freeze the development program for ABX196 in the

treatment of hepatocellular cancer (see Note 3.1 - Impairment of ABX196 cash-generating unit ). Subsequently, in 2024, the licensing

contract was terminated.

Note 25.2. Commitments under BPI conditional advances

Bpifrance CARENA contract

As part of the development of therapeutic and diagnostic solutions targeting alternative splicing and RNA interference in the fields of

virology (HIV-AIDS, HTLV-1) and metabolism (obesity), SPLICOS (absorbed by the Group on 31 October 2014) has entered into a

Master Support Agreement with Bpifrance as well as a conditional advance contract in the name of the “CARENA” Strategic

Industrial Innovation Project dated December 16, 2013. The Group, acting as project leader for the CARENA project, was associated

as part of a consortium contract with Theradiag, a Group specializing in in vitro diagnostics and the development of theranostic tests

for monitoring biotherapies, as well as at the CNRS and the University of Montpellier.

The CARENA project aimed to develop the anti-HIV-AIDS therapeutic program with the compound ABX464 up to the Phase 2b

study, as well as a companion test set up by Theradiag simultaneously with the clinical development. Beyond the anti-HIV-AIDS

program, the CARENA project could extend its pharmacological investigations to another retrovirus that could be combated by the

same approach: HTLV-1.

The Group is committed to reimbursing the received conditional advances up to €3,840 thousand. The Group will also have to pay an

annuity of 50% of the proceeds from the sale of the intellectual property rights resulting from the project, as well as the sale of the

prototypes, preproduction and models produced under the project; the sum due to Bpifrance under this provision will be deducted

from the repayment of the conditional advances. In addition, if the advance is repaid under the conditions outlined above, the Group

will pay to Bpifrance, over a period of five consecutive years after the date on which the repayment schedule ends and provided that

the Group has reached cumulative pre-tax revenue greater than or equal to €50 million, an amount equal to 1.20% of the annual

revenue generated from the sale of the products developed as part of the project. This supplementary payment amount is capped at

€6,800 thousand. The total period, including fixed payments and incentive payments, is limited to 15 years.

In June 2024, the Group and Bpifrance agreed to terminate the project due to technical failure. Termination became effective in

December 2024 after the Group refunded €234 thousand corresponding to a portion of the funding received. The Group is therefore

released of its obligations to pay an annuities on the proceeds from the sale of the intellectual property rights resulting from the

project.

Bpifrance RNP-VIR contract

In pursuit of the CARENA project, focused on the clinical development of a drug molecule and demonstrating the validity of an

innovative therapeutic approach targeting viral RNPs, the Group has entered into a Master Support Agreement with Bpifrance as well

as a beneficiary agreement with conditional advance for the “RNP-VIR” structuring research and development project for

competitiveness dated December 16, 2016.

The RNP-VIR project aimed to further the discovery of new molecules for the treatment of multiple infectious diseases by the

development of the antiviral technology platform. The Group, acting as project leader of the RNP-VIR project, was associated in a

consortium contract with the CNRS and the University of Montpellier.

The Group is committed to reimburse the received conditional advances up to €6,576 thousand. If applicable, the Group will also have

to pay an annuity of 50% of the proceeds from the sale of the intellectual property rights resulting from the project, as well as the sale

of the prototypes, preproduction and models produced under the project. The sum due to Bpifrance under this provision will be

deducted from the last payment (and if needed from the previous payments).

If the advance is repaid under the conditions outlined above, the Group will pay to Bpifrance, over a period of five consecutive years

following the date on which the repayment schedule ends and provided that the Group has reached cumulative pre-tax revenue greater

than or equal to €25 million, an amount equal to 3% of the annual revenue generated from the sale of products developed as part of the

project. The supplementary payments amount is capped at €5,500 thousand. The total period, including fixed payments and incentive

payments, is limited to 15 years.

In June 2024, the Group and Bpifrance agreed to terminate the project due to technical failure. Termination became effective in

December 2024. The Group is therefore released of its obligations to pay an annuities on the proceeds from the sale of the intellectual

property rights resulting from the project.

Bpifrance Ebola

The Bpifrance and Occitanie Region joint support agreement granted on June 2, 2017 consists of conditional advances to the Group

for a total amount of up to €390 thousand, based on the success of the program (respectively €130 thousand from the Languedoc

Roussillon Midi Pyrénées Region and €260 thousand from Bpifrance). In September 2019, the Group decided to terminate this

program, due to the existence of a vaccine in the process of being licensed for this indication as well as changes in the macroeconomic

climate for public funding.

The reimbursement of the conditional advance was spread until June 2024.

Note 25.3. Pledge assets to Kreos, Claret and Heights

As part of the KREOS 1 & 2 bonds, Kreos benefits from first-rate collateral on the Group’s principal tangible and intangible assets,

including its commercial fund, intellectual property rights in its principal drug candidates, as well as a pledge of the Group’s bank

accounts and claims.

On August 21, 2023, the outstanding Kreos 1 & 2 bond loans were repaid in full, using the proceeds from the new Kreos / Claret

Financing (see Note 3.3).

The Kreos / Claret Financing provides for certain restrictive covenants (subject to customary exceptions) which include, among other

things, restrictions on the incurrence of indebtedness, cross-default, the distribution of dividends and the grant of security interests, and

which would cause the bonds to become repayable on demand in case of breach. As of December 31, 2024, the Group complied with

these restrictive covenants.

As security for the Kreos / Claret Financing, the lenders benefit from the grant of first-ranking collateral on the Group’s principal

tangible and intangible assets, including pledges over the Group’s business (fonds de commerce) as a going concern and intellectual

property rights in the Group's lead drug candidate, as well as pledges over the Group’s bank accounts and receivables. Such securities

apply to all tranches of the Kreos / Claret Financing.

The Heights Financing is a senior, unsecured financing. The terms and conditions of the Heights convertible notes include a standard

negative pledge providing that any security granted in favor of other borrowed debt or debt instruments should also be granted in favor

of the Heights convertible notes on an equal basis (with the exception of the securities issued pursuant to the Kreos / Claret Financing,

as detailed above).

Note 25.4. Other commitments related to research and partnership arrangements

In the ordinary course of business, the Group regularly uses the services of subcontractors and enters into research and partnership

arrangements with various contract research organizations, or CROs, and with public- sector partners or subcontractors, who conduct

clinical trials and studies in relation to the drug candidates.

At December 31, 2022, 2023, and 2024 the Group’s commitments amounted to €194,731 thousand, €201,777 thousand and €234,908

thousand. The cost of services performed by CROs is recognized as an operating expense as incurred.

Note 25.5. Leases

Following the end (in December 31, 2021) of the Framework agreement with CNRS (French National Centre for Scientific Research)

and the University of Montpellier for research collaboration to create a cooperative laboratory, a hosting agreement was signed in

2022 with CNRS, so that the Group can continue its research program at the CNRS center for the year 2023, and was subsequently

renewed for 2024 and 2025.

In December 2022, following the end of the Research collaboration contract with the CNRS, the University of Montpellier and the

Institut Curie, the Company and the Institut Curie concluded a new contract for a duration of one year, renewable by amendment,

granting the Company access to some of the Institute’s equipment and consumables. The contract was subsequently renewed for 2024

and 2025, under similar conditions.

The above agreements fall within the scope of the short-term lease exemption of IFRS 16, and the related rental expenses are therefore

recognized in operating expenses as incurred.

The Group's commitments in relation to other ongoing leases are set forth in Note 15.8 and 15.13.

Note 25.6. Litigation related to Prosynergia acquisition

On December 12, 2024, the Group was notified of a claim from the seller of Prosynergia requesting the payment of an earn-out in

connection with the transaction. Legal proceedings are ongoing in French court. The Group has not recorded any provision in its

financial statements in connection with this claim due to uncertainty in the outcome of this proceeding.