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CONSOLIDATED STATEMENTS OF CASH FLOWS € in Thousands, $ in Millions | 12 Months Ended
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Dec. 31, 2025 EUR (€) | Dec. 31, 2024 EUR (€) | Dec. 31, 2023 EUR (€)
Cash flows provided by (used in) operating activities |  |  |
Net loss for the period | € (336,102) | € (176,242) | € (147,740)
Adjustments for: |  |  |
Amortization of intangibles and depreciation of property, plant and equipment | 1,072 | 1,100 | 707
Retirement benefit obligations | (65) | 74 | 109
Share-based compensation expenses | 35,397 | 20,224 | 8,179
Net gain on sale of treasury shares | 0 | (16) | (34)
Interest expenses and other financial expenses | 45,697 | 14,203 | 24,827
Financial income | (23,782) | (11,609) | (2,953)
Effect of unwinding the discount related to advances | (153) | (710) | (355)
Increase/(decrease) in derivatives and liabilities measured at fair value | 62,330 | 1,416 | (1,158)
Forgiveness of conditional advances | 0 | (4,140) | 0
Changes in provisions | 44,706 | 0 | 0
Current and deferred taxes expenses | 5,848 | 0 | 0
Other | 270 | 204 | 22
Cash flows provided by (used in) operating activities before change in working capital requirements | (164,780) | (155,495) | (118,395)
Decrease / (increase) in other receivables and related accounts | 7,042 | 4,591 | (14,231)
Increase / (decrease) in trade payables | (6,210) | (3,444) | 31,757
Increase / (decrease) in tax and social security liabilities | 2,110 | (1,487) | 3,821
Changes in deferred income and other liabilities | 710 | 1,763 | (81)
Changes in working capital requirements | 3,651 | 1,423 | 21,265
Income taxes paid | 0 | 0 | 0
Cash flows provided by (used in) operating activities | (161,129) | (154,072) | (97,130)
Cash flows provided by (used in) investing activities |  |  |
Acquisitions of intangible assets | 0 | (3) | 0
Acquisitions of property, plant and equipment | (142) | (640) | (265)
Advances reimbursed by / (made to) CROs | 71 | (231) | (1,620)
Increase in deposits | (14,152) | (591) | (9,351)
Decrease in deposits | 500 | 9,050 | 741
Interest received | 5,530 | 8,178 | 2,400
Cash flows provided by (used in) investing activities | (8,193) | 15,762 | (8,095)
Cash flows provided by (used in) financing activities |  |  |
Capital increases | 648,124 | 0 | 353,377
Transaction costs related to capital increase | (40,914) | 446 | (28,111)
Net proceeds from non-convertible bond loans | 0 | 47,944 | 0
Repayments of non-convertible bond loans | (53,920) | 0 | (11,635)
Net proceeds from convertible loan notes | 0 | 0 | 55,841
Repayments of convertible loan notes | (2,188) | (8,750) | (27,188)
Repayment of PGE | (2,514) | (1,250) | (1,250)
Repayments of conditional advances | 0 | (2,708) | (110)
Payments of the lease liabilities | (911) | (458) | (529)
Net proceeds from sale of treasury shares | 0 | 434 | 10
Interest paid | (6,490) | (7,696) | (5,279)
Exercise of warrants | 5,820 | 0 | 0
Other | 300 | 245 | 163
Cash flows provided by (used in) financing activities | 547,307 | 28,207 | 335,290
Effect of movements in exchange rates on cash held | (10,251) | 2,382 | (5,072)
Revaluation of cash equivalents measured at fair value | 4,730 | 0 | 0
Increase (decrease) in cash and cash equivalents | 372,464 | (107,720) | 224,992
Cash and cash equivalents at the beginning of the year | 144,221 | 251,942 | 26,950
Cash and cash equivalents at the end of the year | € 516,685 | € 144,221 | € 251,942

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- Definition The cash outflow for payment of lease liabilities, classified as financing activities. [Refer: Lease liabilities] + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Name IAS -Number 7 -IssueDate 2025-01-01 -Paragraph 17 -Subparagraph e -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=7&code=ifrs-tx-2025-en-r&anchor=para_17_e&doctype=Standard -URIDate 2025-03-27 + Details
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- Definition The cash inflow from the exercise of share purchase warrants. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Name IAS -Number 7 -IssueDate 2025-01-01 -Paragraph 17 -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=7&code=ifrs-tx-2025-en-r&anchor=para_17&doctype=Standard -URIDate 2025-03-27 + Details
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- Definition The cash inflow from issuing shares. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Name IAS -Number 7 -IssueDate 2025-01-01 -Paragraph 17 -Subparagraph a -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=7&code=ifrs-tx-2025-en-r&anchor=para_17_a&doctype=Standard -URIDate 2025-03-27 + Details
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- Definition The cash inflow from the sale or issuing of treasury shares. [Refer: Sale or issue of treasury shares; Treasury shares] + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Name IAS -Number 7 -IssueDate 2025-01-01 -Paragraph 17 -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=7&code=ifrs-tx-2025-en-r&anchor=para_17&doctype=Standard -URIDate 2025-03-27 + Details
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- Definition The cash outflow for the purchases of intangible assets, classified as investing activities. [Refer: Intangible assets other than goodwill] + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Name IAS -Number 7 -IssueDate 2025-01-01 -Paragraph 16 -Subparagraph a -URI https://taxonomy.ifrs.org/xifrs-link?type=IAS&num=7&code=ifrs-tx-2025-en-r&anchor=para_16_a&doctype=Standard -URIDate 2025-03-27 + Details
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