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v3.26.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2026 | Mar. 31, 2025
Cash flows from operating activities: |  |
Net loss | $ (206,031) | $ (161,376)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash interest expense on liabilities related to revenue participation right purchase agreements | 18,816 | 14,104
Stock-based compensation expense | 30,394 | 23,549
Non-cash lease expense | 1,585 | 1,230
Depreciation of property and equipment | 3,378 | 2,300
Change in fair value of derivative liabilities | (1,500) | 400
Change in fair value of liabilities related to RPI Transactions | 1,600 | (3,900)
Realized gain on investment, net | (61) | 0
Interest receivable and amortization on investments | (1,874) | (6,174)
Non-cash interest expense related to debt | 8,455 | 3,453
Changes in operating assets and liabilities: |  |
Accounts receivable | 10,937 | 14,638
Prepaid and other assets | 2,057 | (376)
Inventories | (3,567) | 0
Accounts payable | 1,519 | (4,576)
Deferred revenue | 41 | 0
Accrued and other liabilities | (6,213) | (14,367)
Operating lease liabilities | (1,039) | (2,143)
Other non-current liabilities | (3,954) | 1,621
Net cash used in operating activities | (145,457) | (131,617)
Cash flows from investing activities: |  |
Purchases of investments | (106,516) | (159,105)
Investment in non-marketable equity security | 0 | (5,000)
Maturities of investments | 257,938 | 275,725
Purchases of property and equipment | (5,930) | (5,664)
Net cash provided by investing activities | 145,492 | 105,956
Cash flows from financing activities: |  |
Repayment of finance lease liabilities | 0 | (202)
Repayment of term loans | (2,735) | (2,682)
Proceeds from issuance of common stock under equity incentive and stock purchase plans | 11,346 | 7,651
Taxes paid related to net share settlement of equity awards | (841) | (13)
Net cash provided by financing activities | 7,770 | 4,754
Effect of exchange rate changes on cash | (483) | (270)
Net (decrease) increase in cash, cash equivalents, and restricted cash | 7,322 | (21,177)
Cash, cash equivalents, and restricted cash, beginning of period | 125,632 | 95,232
Cash, cash equivalents, and restricted cash, end of period | 132,954 | 74,055
Supplemental cash flow disclosures: |  |
Cash paid for interest | 1,585 | 9,647
Non-cash investing and financing activities: |  |
Right-of-use assets recognized in exchange for operating lease obligations | 170 | 3,501
Amounts unpaid for purchases of property and equipment | $ 4,186 | $ 1,494

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