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Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities |  |  |
Net loss | $ (118,009) | $ (44,355) | $ (24,734)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |  |  |
Depreciation | 639 | 373 | 348
Stock-based compensation expense | 17,056 | 4,310 | 406
Amortization of premiums and discounts on marketable securities, net | 179 | 9 | 0
Amortization of discounts and loan issuance costs | 0 | 29 | 71
Gain on disposal of property and equipment | (16) | 0 | 0
Noncash interest expense | 0 | 110 | 7,027
Change in fair value of preferred warrant liability | 0 | 75 | 15
Changes in operating assets and liabilities: |  |  |
Prepaid and other assets | (2,510) | (2,444) | (949)
Accounts payable and accrued liabilities | 6,043 | 5,749 | 436
Accrued compensation | 5,788 | 1,838 | 1,010
Operating lease right-of-use assets and liabilities, net | 461 | 289 | (80)
Deferred revenue | (4,444) | (3,100) | 18,940
Net cash (used in) provided by operating activities | (94,813) | (37,117) | 2,490
Cash flows from investing activities |  |  |
Purchases of marketable securities | (85,357) | (6,693) | 0
Maturities of marketable securities | 6,580 | 0 | 0
Purchases of property and equipment | (3,740) | (1,092) | (235)
Net cash used in investing activities | (82,517) | (7,785) | (235)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock in public offerings, gross | 185,939 | 298,080 | 0
Payment of issuance costs related to public offerings | (11,262) | (24,026) | 0
Proceeds from exercise of stock/unit options, net of repurchases | 930 | 22 | 65
Proceeds from issuance of common stock under employee stock purchase plan | 709 | 444 | 0
Payments on long-term debt | 0 | (4,683) | (2,800)
Distributions to members | 0 | 0 | (106)
Proceeds from issuance of Series C convertible preferred stock, net of issuance costs | 0 | 2,200 | 72,623
Proceeds from issuance of convertible notes, net of issuance costs | 0 | 0 | 19,451
Net cash provided by financing activities | 176,316 | 272,037 | 89,233
Net (decrease) increase in cash, cash equivalents and restricted cash | (1,014) | 227,135 | 91,488
Cash, cash equivalents and restricted cash at beginning of period | 321,713 | 94,578 | 3,090
Cash, cash equivalents and restricted cash at end of period | 320,699 | 321,713 | 94,578
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 0 | 571 | 322
Supplemental schedule of noncash investing and financing activities: |  |  |
Right-of-use assets obtained in exchange for operating lease liabilities | 12,074 | 936 | 807
Costs incurred, but not paid, in connection with purchases of property and equipment included in accounts payable and accrued liabilities | 220 | 118 | 43
Conversion of convertible preferred stock into common stock upon completion of initial public offering | 0 | 136,920 | 0
Issuance of Series C convertible preferred stock upon conversion of outstanding convertible notes | 0 | 0 | 29,510
Reclassification of warrant liability to equity due to adjustment from preferred stock warrant to common stock warrant upon completion of initial public offering | $ 0 | $ 120 | $ 0

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