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Commitments and Contingencies - Additional Information (Details) - USD ($) |  | 12 Months Ended
--- | --- | ---
Dec. 18, 2020 | Dec. 31, 2021
Commitments and Contingencies [Line Items] |  |
Operating lease, description |  | During the periods presented, the Company was party to various non-cancellable office and laboratory space operating leases and short-term leases. Currently, the Company is only party to a non-cancellable office and laboratory space operating lease. Under the relevant guidance, the Company recognizes operating lease right-of-use (ROU) assets and liabilities based on the present value of the future minimum lease payments over the lease term at the commencement date, using the Company’s assumed incremental borrowing rate of 5.5%, and amortizes the ROU assets and liabilities over the lease term. Lease expense for operating leases is recognized on a straight-line basis over the lease term. The Company’s short-term leases are not subject to recognition of an ROU asset or liability or straight-line lease expense requirements.
Incremental borrowing rate |  | 5.50%
Weighted-average remaining term of operating leases |  | 4 years 10 months 24 days
Loss contingencies accrued |  | $ 0
Lease Term through November 2017 | Office and Laboratory Space |  |
Commitments and Contingencies [Line Items] |  |
Operating lease, term of contract, description |  | In March 2014, the Company entered into a non-cancellable operating lease for office and laboratory space with a lease term through November 2017.
Lease Term through December 2021 | Office and Laboratory Space |  |
Commitments and Contingencies [Line Items] |  |
Operating lease, term of contract, description |  | In July 2017, the Company entered into an amendment to this lease to extend the lease term through December 2021.
New Lease | Office and Laboratory Space |  |
Commitments and Contingencies [Line Items] |  |
Operating lease, description | On December 18, 2020, the Company entered into an amendment to the non-cancellable operating lease for its new headquarters location (as amended, the New Lease), which increased the square footage by adding adjacent space and extended the projected commencement date to November 1, 2021. Additionally, the non-cancellable temporary operating lease was amended (as amended, the Temporary Lease) to accommodate the projected commencement date of the New Lease. | On June 1, 2020, the Company entered into a second amendment to its existing operating lease (as amended, the 2014 Lease) and entered into a new non-cancellable temporary operating lease in connection with a newly executed non-cancellable operating lease for its new headquarters location, with a projected commencement date of July 1, 2021.
Operating lease, lease payment under new lease | $ 14,700,000 |
Operating lease, term of contract | 5 years |
Operating lease, renewal term | 5 years |
Lessee, operating lease, existence of option to extend [true false] | true |
Operating lease, initial monthly base rent | $ 251,000 |
Operating lease, monthly base rent for last year lease | 282,000 |
Letter of credit throughout the lease term | $ 251,000 |
Temporary Lease | Office and Laboratory Space |  |
Commitments and Contingencies [Line Items] |  |
Operating lease, expiration period, description | The lease term under both the 2014 Lease and the Temporary Lease ends 15 days after the commencement date of the New Lease in November 2021. |
Operating lease expiration period | 15 days |

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