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Collaboration, License and Research Agreements - Additional Information (Details) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2019 shares | Apr. 30, 2019 USD ($) Product | Dec. 31, 2021 USD ($) Obligation | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Revenue recognized |  |  | $ 9,326,000 | $ 6,787,000 | $ 2,319,000
Lilly Note | Series C Convertible Preferred Stock |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Conversion of convertible note payable to preferred stock | shares | 4,576,342 |  |  |  |
Research Collaboration and License Agreement with Eli Lilly |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Upfront fees received |  | $ 20,000,000.0 |  |  |
License agreement expiry period |  | 10 years |  |  |
Number of performance obligation | Obligation |  |  | 1 |  |
Period for expects performance obligation |  |  | 5 years |  |
Revenue recognized |  |  | $ 9,100,000 | 6,800,000 | 2,300,000
Deferred revenue |  |  | 11,108,000 | 15,840,000 | $ 18,940,000
Research Collaboration and License Agreement with Eli Lilly | Prepaid and Other Assets |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Collaboration receivables |  |  | 900,000 | 1,200,000 |
Research Collaboration and License Agreement with Eli Lilly | Maximum |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Rights to antibody oligonucleotide conjugates for messengers RNA targets. | Product |  | 6 |  |  |
Development milestone payment eligible to receive per target |  | $ 60,000,000.0 |  |  |
Regulatory milestone payment eligible to receive per target |  | 140,000,000.0 |  |  |
Commercialization milestone payment eligible to receive |  | $ 205,000,000.0 |  |  |
Research Collaboration with MyoKardia, Inc. |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Revenue recognized |  |  | $ 200,000 | $ 0 |

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