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Income Taxes - Additional Information (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Income Taxes Disclosure [Line Items] |  |  |
Provision for income taxes | $ 0 | $ 0 | $ 0
Increase in the valuation allowance | 35,400,000 | 13,500,000 |
Accruals for interest or penalties | 0 | 0 |
Interest or penalties | 0 | $ 0 |
Federal |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss (NOL) carryforwards | $ 147,900,000 |  |
Net operating loss available to offset against current taxable income percentage | 100.00% |  |
Net operating loss available to offset against future taxable income percentage | 80.00% |  |
Federal and state tax credit carryforwards | $ 4,700,000 |  |
Tax credit expiration beginning year | 2039 |  |
Federal | Orphan Drug Tax Credits |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Federal and state tax credit carryforwards | $ 700,000 |  |
Tax credit expiration beginning year | 2041 |  |
State |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss (NOL) carryforwards | $ 147,700,000 |  |
Net operating loss carryforwards, expiration beginning year | 2039 |  |
Federal and state tax credit carryforwards | $ 2,600,000 |  |

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- Definition Amount, before allocation of a valuation allowances, of deferred tax assets attributable to deductible tax credit carryforwards including, but not limited to, research, foreign, general business, alternative minimum tax, and other deductible tax credit carryforwards. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32632-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32559-109319 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32621-109319 + Details
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