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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2021
Income Tax Disclosure [Abstract] |
Reconciliation of Income Taxes Computed by Applying Statutory Federal Income Tax Rate | A reconciliation of income taxes to the amount computed by applying the statutory federal income tax rate to the net loss is summarized as follows (in thousands):
|  | Year Ended December 31, |
|  | 2021 |  |  | 2020 |  |  | 2019 |
Income tax expense (benefit) at statutory rates |  | $ | (24,784 | ) |  | $ | (9,315 | ) |  | $ | (5,194 | )
State income tax, net of federal benefit |  |  | (7,868 | ) |  |  | (3,004 | ) |  |  | (1,057 | )
Permanent items |  |  | 210 |  |  |  | 1 |  |  |  | 14 |
Book income for pre-conversion period |  |  | — |  |  |  | — |  |  |  | 527 |
Interest on convertible notes |  |  | — |  |  |  | — |  |  |  | 445 |
Realized gain on conversion of convertible notes |  |  | — |  |  |  | — |  |  |  | 958 |
Reserve for uncertain tax positions |  |  | 1,170 |  |  |  | 398 |  |  |  | 140 |
Research and development tax credits |  |  | (4,792 | ) |  |  | (1,639 | ) |  |  | (584 | )
Deferred taxes recognized upon conversion |  |  | — |  |  |  | — |  |  |  | (3,076 | )
Valuation allowance |  |  | 35,326 |  |  |  | 13,488 |  |  |  | 7,827 |
Other |  |  | 738 |  |  |  | 71 |  |  |  | — |
Income tax expense (benefit) |  | $ | — |  |  | $ | — |  |  | $ | — |
Components of Deferred Tax Assets | Significant components of the Company’s deferred tax assets as of December 31, 2021 and 2020 are shown below (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 41,443 |  |  | $ | 11,277 |
Research and development tax credits |  |  | 5,586 |  |  |  | 1,855 |
Deferred revenue |  |  | 3,117 |  |  |  | 4,443 |
Accrued expenses |  |  | 477 |  |  |  | 153 |
Intangibles and fixed assets |  |  | 2,137 |  |  |  | 2,483 |
Lease liability |  |  | 3,291 |  |  |  | 263 |
Stock-based compensation |  |  | 3,668 |  |  |  | 969 |
Total deferred tax assets |  |  | 59,719 |  |  |  | 21,443 |
Less valuation allowance |  |  | (56,693 | ) |  |  | (21,316 | )
Net deferred tax assets |  |  | 3,026 |  |  |  | 127 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Right-of-use asset |  |  | (3,026 | ) |  |  | (127 | )
Total deferred tax liabilities |  |  | (3,026 | ) |  |  | (127 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |
Summarizes of Activity Related to Gross Unrecognized Tax Benefits | The following table summarizes the activity related to the Company’s gross unrecognized tax benefits for the years ended December 31, 2021 and 2020 (in thousands):
|  | Year Ended December 31, |
|  | 2021 |  |  | 2020 |
Gross unrecognized tax benefits at the beginning of the year |  | $ | 671 |  |  | $ | 156 |
Increases related to current year positions |  |  | 1,283 |  |  |  | 446 |
Increases related to prior year positions |  |  | 42 |  |  |  | 62 |
Other true up |  |  | — |  |  |  | 7 |
Gross unrecognized tax benefits at the end of the year |  | $ | 1,996 |  |  | $ | 671 |

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