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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities |  |  |
Net loss | $ (322,302) | $ (212,220) | $ (173,995)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 2,776 | 2,101 | 1,387
Stock-based compensation expense | 51,363 | 38,222 | 27,139
Amortization of premiums and discounts on marketable securities, net | (21,447) | (11,274) | (615)
Noncash operating lease costs | 3,297 | 2,978 | 2,749
Changes in operating assets and liabilities: |  |  |
Prepaid and other assets | (25,057) | (3,444) | (6,616)
Accounts payable and accrued liabilities | 35,183 | 1,769 | 18,315
Accrued compensation | (10,672) | 3,145 | 2,250
Operating lease liabilities | (3,696) | (3,328) | (1,762)
Deferred revenue | (10,315) | 62,987 | (5,120)
Net cash used in operating activities | (300,870) | (119,064) | (136,268)
Cash flows from investing activities |  |  |
Purchases of marketable securities | (1,433,535) | (461,002) | (355,837)
Maturities of marketable securities | 586,400 | 335,160 | 168,705
Purchases of property and equipment | (7,066) | (4,228) | (2,823)
Net cash used in investing activities | (854,201) | (130,070) | (189,955)
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock in public offerings, net of issuance costs | 762,161 | 60,547 | 344,779
Proceeds from issuance of common stock in private placements, net of issuance costs and allocation to deferred revenues (Note 5) | 238,388 | 31,190 | 0
Proceeds from issuance of pre-funded warrants in a private placement, net of issuance costs | 141,395 | 0 | 0
Proceeds from the issuance of common stock under employee incentive equity plans | 50,413 | 2,127 | 1,392
Net cash provided by financing activities | 1,192,357 | 93,864 | 346,171
Net increase (decrease) in cash, cash equivalents and restricted cash | 37,286 | (155,270) | 19,948
Cash, cash equivalents and restricted cash at beginning of period | 185,377 | 340,647 | 320,699
Cash, cash equivalents and restricted cash at end of period | 222,663 | 185,377 | 340,647
Supplemental schedule of noncash investing and financing activities: |  |  |
Right-of-use assets obtained in exchange for operating lease liabilities | 0 | 1,741 | 0
Costs incurred, but not paid, in connection with purchases of property and equipment included in accounts payable and accrued liabilities | $ 3,424 | $ 0 | $ 233

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 28 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-28 + Details
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