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v3.25.0.1

Collaboration, License and Research Agreements - Additional Information (Details) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Nov. 27, 2023 USD ($) shares | Nov. 30, 2023 USD ($) $ / shares shares | Apr. 30, 2019 USD ($) Product Obligation | Dec. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Collaboration revenue |  |  |  | $ 10,897 | $ 9,560 | $ 9,224
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront fees received |  | $ 100,000 |  |  |  |
Collaborative arrangement, nonrefundable cash payment received |  | 60,000 |  |  |  |
Sale of stock, consideration received on transaction |  | 40,000 |  |  |  |
Cumulative spending cap |  | 40,000 |  |  |  |
Collaboration revenue |  |  |  | $ 9,800 | 0 |
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-01-01 |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue, remaining performance obligation, period |  |  |  | 7 years |  |
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS | First Unit Of Accounting |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue, remaining performance obligation, amount |  | 68,700 |  |  |  |
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS | Second Unit Of Accounting |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Revenue, remaining performance obligation, amount |  | $ 31,300 |  |  |  |
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS | Private Placement |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Sale of stock number of shares issued in transaction (in shares) | shares | 5,075,304 | 5,075,304 |  |  |  |
Sale of stock, consideration received on transaction | $ 40,000 | $ 40,000 |  |  |  |
Sale of stock, price per share (in dollars per share) | $ / shares |  | $ 7.8813 |  |  |  |
Premium In excess of fair value | $ 8,700 | $ 8,700 |  |  |  |
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS | Maximum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Development milestone payment eligible to receive |  | 1,350,000 |  |  |  |
Commercialization milestone payment eligible to receive |  | $ 825,000 |  |  |  |
Research Collaboration and License Agreement with Eli Lilly |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront fees received |  |  | $ 20,000 |  |  |
Collaboration revenue |  |  |  | $ 1,100 | 9,500 | $ 9,000
License agreement expiry period |  |  | 10 years |  |  |
Number of performance obligation | Obligation |  |  | 1 |  |  |
Period for expected performance obligation |  |  |  | 5 years |  |
Collaboration receivables |  |  |  | $ 0 | $ 800 |
Research Collaboration and License Agreement with Eli Lilly | Maximum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Development milestone payment eligible to receive |  |  | $ 60,000 |  |  |
Commercialization milestone payment eligible to receive |  |  | $ 205,000 |  |  |
Rights to antibody oligonucleotide conjugates for messengers RNA targets. | Product |  |  | 6 |  |  |
Regulatory milestone payment eligible to receive |  |  | $ 140,000 |  |  |

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