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Stockholders' Equity - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
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Aug. 16, 2024 | Aug. 09, 2024 | Jun. 17, 2024 | Mar. 04, 2024 | Nov. 27, 2023 | Nov. 08, 2022 | Nov. 30, 2023 | Jun. 30, 2020 | Mar. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Jun. 16, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares authorized (in shares) |  |  |  |  |  |  |  |  |  | 400,000,000 | 400,000,000 |  | 400,000,000
Preferred stock, shares authorized (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 40,000,000
Common stock, par value (in dollars per share) |  |  |  |  |  |  |  |  |  | $ 0.0001 | $ 0.0001 |  | $ 0.0001
Preferred stock, par value (in dollars per share) |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.0001
Preferred stock, shares outstanding (in shares) |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |
Proceeds from issuance of common stock in public offerings, net of issuance costs |  |  |  |  |  |  |  |  |  | $ 762,161 | $ 60,547 | $ 344,779 |
Award vesting period |  |  |  |  |  |  |  |  |  | 4 years |  |  |
Total stock-based compensation expense |  |  |  |  |  |  |  |  |  | $ 51,363 | 38,222 | 27,139 |
Expected dividend yield |  |  |  |  |  |  |  |  |  | 0.00% |  |  |
Unrecognized compensation cost, options |  |  |  |  |  |  |  |  |  | $ 102,500 |  |  |
Forecast |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
PSUs vested (in shares) |  |  |  |  |  |  |  |  | 187,500 |  |  |  |
Restricted stock units |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Total stock-based compensation expense |  |  |  |  |  |  |  |  |  | $ 7,000 | $ 900 | $ 0 |
PSUs vested (in shares) |  |  |  |  |  |  |  |  |  | 184,293 | 0 | 0 |
Fair value of shares vested during the period |  |  |  |  |  |  |  |  |  | $ 3,500 |  |  |
Granted (in shares) |  |  |  |  |  |  |  |  |  | 1,711,000 |  |  |
Unrecognized compensation cost, excluding options |  |  |  |  |  |  |  |  |  | $ 45,200 |  |  |
Performance Stock Units (PSUs) |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Total stock-based compensation expense |  |  |  |  |  |  |  |  |  | $ 4,800 | $ 0 | $ 0 |
PSUs vested (in shares) |  |  |  |  |  |  |  |  |  | 562,500 | 0 | 0 |
Fair value of shares vested during the period |  |  |  |  |  |  |  |  |  | $ 22,100 |  |  |
Outstanding PSUs (in shares) |  |  |  |  |  |  |  |  |  | 750,000 |  |  |
Granted (in shares) |  |  |  |  |  |  |  |  |  | 738,000 |  |  |
Unrecognized compensation cost, excluding options |  |  |  |  |  |  |  |  |  | $ 32,100 |  |  |
Unrecognized compensation cost, probable amount |  |  |  |  |  |  |  |  |  | $ 200 |  |  |
Employee Stock |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Shares available for grant (in shares) |  |  |  |  |  |  |  |  |  | 193,367 |  |  |
Participant maximum contribution as percentage of eligible compensation |  |  |  |  |  |  |  | 15.00% |  |  |  |  |
Award offering period |  |  |  |  |  |  |  | 6 months |  | 6 months |  |  |
Percentage of purchase price of shares of lower of fair market value |  |  |  |  |  |  |  | 85.00% |  |  |  |  |
Issuance of common stock under employee stock purchase plan (in shares) |  |  |  |  |  |  |  |  |  | 179,150 | 175,511 | 90,535 |
Outstanding liability |  |  |  |  |  |  |  |  |  | $ 300 |  |  |
Expected dividend yield |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00% |
Unrecognized compensation cost, excluding options |  |  |  |  |  |  |  |  |  | $ 900 |  |  |
Weighted-average period of unrecognized compensation cost |  |  |  |  |  |  |  |  |  | 6 months |  |  |
Common stock options issued and outstanding |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Expected dividend yield |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00% |
Weighted-average period of unrecognized compensation cost |  |  |  |  |  |  |  |  |  | 2 years 8 months 12 days |  |  |
Weighted Average | Restricted stock units |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Weighted-average period of unrecognized compensation cost |  |  |  |  |  |  |  |  |  | 3 years 2 months 12 days |  |  |
Weighted Average | Performance Stock Units (PSUs) |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Weighted-average period of unrecognized compensation cost |  |  |  |  |  |  |  |  |  | 2 months 12 days |  |  |
2020 Incentive Award Plan |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Shares of common stock reserved for future issuance (in shares) |  |  |  |  |  |  |  | 3,900,000 |  |  |  |  |
Percentage of shares of common stock outstanding on final day of immediately preceding calendar year |  |  |  |  |  |  |  | 5.00% |  |  |  |  |
Shares available for grant (in shares) |  |  |  |  |  |  |  |  |  | 1,591,462 |  |  |
Additional shares reserved for future issuance (in shares) |  |  |  |  |  |  |  |  |  | 3,963,742 |  |  |
2020 Incentive Award Plan | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Expiration period |  |  |  |  |  |  |  |  |  | 10 years |  |  |
2022 Employment Inducement Incentive Award Plan |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Shares of common stock reserved for future issuance (in shares) |  |  |  |  |  |  |  |  |  |  |  | 4,500,000 |
Shares available for grant (in shares) |  |  |  |  |  |  |  |  |  | 697,350 |  |  |
Additional shares reserved for future issuance (in shares) |  |  |  |  |  |  |  |  |  | 3,000,000 |  |  |
2022 Employment Inducement Incentive Award Plan | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Expiration period |  |  |  |  |  |  |  |  |  | 10 years |  |  |
2013 Equity Incentive Plan | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Expiration period |  |  |  |  |  |  |  |  |  | 10 years |  |  |
Pre-Funded Common Stock Warrant |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of warrant or right, exercise price (in dollar per share) |  |  |  |  |  |  |  |  |  | $ 0.001 |  |  |
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock, consideration received on transaction |  |  |  |  |  |  | $ 40,000 |  |  |  |  |  |
Private Placement |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Public offering issuance costs |  |  |  |  |  |  |  |  |  | $ 12,821 | $ 74 |  |
Issuance of common stock, net of issuance costs |  |  |  |  |  |  |  |  |  | 238,388 | 31,190 |  |
Private Placement | Research Collaboration, License Agreement and Securities Purchase Agreement with BMS |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock number of shares issued in transaction (in shares) |  |  |  |  | 5,075,304 |  | 5,075,304 |  |  |  |  |  |
Public offering issuance costs |  |  |  |  | $ 100 |  |  |  |  |  |  |  |
Sale of stock, consideration received on transaction |  |  |  |  | 40,000 |  | $ 40,000 |  |  |  |  |  |
Issuance of common stock, net of issuance costs |  |  |  |  | 31,200 |  |  |  |  |  |  |  |
Premium In excess of fair value |  |  |  |  | $ 8,700 |  | $ 8,700 |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) |  |  |  |  |  |  | $ 7.8813 |  |  |  |  |  |
Private Placement Offering 2024 |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock number of shares issued in transaction (in shares) |  |  |  | 15,224,773 |  |  |  |  |  |  |  |  |
Sale of stock, consideration received on transaction |  |  |  | $ 379,800 |  |  |  |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) |  |  |  | $ 16.50 |  |  |  |  |  |  |  |  |
Payments of stock issuance costs |  |  |  | $ 20,400 |  |  |  |  |  |  |  |  |
Private Placement Offering 2024 | Principal Owner |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock number of shares issued in transaction (in shares) |  |  |  | 2,121,213 |  |  |  |  |  |  |  |  |
Sale of stock, consideration received on transaction |  |  |  | $ 35,000 |  |  |  |  |  |  |  |  |
Private Placement Offering 2024 | Pre-Funded Common Stock Warrant |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Class of warrant or right, number of securities called by warrants or rights (in shares) |  |  |  | 9,030,851 |  |  |  |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) |  |  |  | $ 16.499 |  |  |  |  |  |  |  |  |
Class of warrant or right, exercise price (in dollar per share) |  |  |  | $ 0.001 |  |  |  |  |  |  |  |  |
Public Stock Offering |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock number of shares issued in transaction (in shares) | 8,418,000 |  | 12,132,500 |  |  |  |  |  |  |  |  |  |
Public offering issuance costs |  |  |  |  |  |  |  |  |  | 49,749 | 1,385 | $ 18,230 |
Sale of stock, consideration received on transaction | $ 323,700 |  | $ 432,800 |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of issuance costs |  |  |  |  |  |  |  |  |  | $ 762,161 | $ 60,547 | $ 344,616 |
Sale of stock, price per share (in dollars per share) | $ 41.00 |  | $ 38.00 |  |  |  |  |  |  |  |  |  |
Payments of stock issuance costs | $ 21,400 |  | $ 28,300 |  |  |  |  |  |  |  |  |  |
Sales Agent | Private Placement, 2022 Sales Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of common stock maximum aggregate offering price |  |  |  |  |  | $ 200,000 |  |  |  |  |  |  |
Sales Agent | Private Placement, 2021 Sales Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock number of shares issued in transaction (in shares) |  |  |  |  |  |  |  |  |  | 418,408 | 4,107,810 |  |
Proceeds from issuance of common stock in public offerings, net of issuance costs |  |  |  |  |  |  |  |  |  | $ 5,600 | $ 60,500 |  |
Public offering issuance costs |  |  |  |  |  |  |  |  |  | $ 100 | $ 1,400 |  |
TD Securities (USA), LLC | Private Placement 2024 Sales Agreement |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock number of shares issued in transaction (in shares) |  |  |  |  |  |  |  |  |  | 0 |  |  |
Sale of common stock maximum aggregate offering price |  | $ 400,000 |  |  |  |  |  |  |  |  |  |  |

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