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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Income Taxes Disclosure [Line Items] |  |  |
Provision for income taxes | $ 0 | $ 0 | $ 0
Increase in the valuation allowance | 98,800 | 61,300 |
Unrecognized tax benefits that would impact effective tax rate | 0 |  |
Accruals for interest or penalties | 0 | $ 0 |
Federal |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss (NOL) carryforwards | 249,400 |  |
Federal and state tax credit carryforwards | 13,300 |  |
Federal | Orphan Drug Tax Credits |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Federal and state tax credit carryforwards | 58,000 |  |
State |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss (NOL) carryforwards | 439,300 |  |
Federal and state tax credit carryforwards | $ 15,800 |  |

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- Definition Amount, before allocation of a valuation allowances, of deferred tax assets attributable to deductible tax credit carryforwards including, but not limited to, research, foreign, general business, alternative minimum tax, and other deductible tax credit carryforwards. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 6 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-6 + Details
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