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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Income Statement [Abstract]      
Collaboration revenue $ 10,897 $ 9,560 $ 9,224
Operating expenses:      
Research and development 303,593 190,968 150,404
General and administrative 86,240 54,190 37,733
Total operating expenses 389,833 245,158 188,137
Loss from operations (378,936) (235,598) (178,913)
Other income (expense):      
Interest income 56,882 23,972 4,975
Other expense (248) (594) (57)
Total other income 56,634 23,378 4,918
Net loss $ (322,302) $ (212,220) $ (173,995)
Net loss per share, basic (in dollars per share) $ (2.89) $ (2.91) $ (3.34)
Net loss per share, diluted (in dollars per share) $ (2.89) $ (2.91) $ (3.34)
Weighted-average shares outstanding, basic (in shares) 111,582 73,012 52,162
Weighted-average shares outstanding, diluted (in shares) 111,582 73,012 52,162
Other comprehensive income (loss):      
Net unrealized gains (losses) on marketable securities $ 2,777 $ 2,823 $ (2,511)
Comprehensive loss $ (319,525) $ (209,397) $ (176,506)