Percentage of shares of common stock outstanding on final day of immediately preceding calendar year.

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Sale of common stock maximum aggregate offering price.

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Sale of Stock, Consideration Received On Transaction, Premium In Excess Of Fair Value

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Share-Based Compensation Arrangement By Share-Based Payment Award, Award Offering Period

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Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Probable Amount

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Amount of decrease in additional paid in capital (APIC) resulting from direct costs associated with issuing stock. Includes, but is not limited to, legal and accounting fees and direct costs associated with stock issues under a shelf registration.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Exercise price per share or per unit of warrants or rights outstanding.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Aggregate number of common shares reserved for future issuance.

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Face amount or stated value per share of common stock.

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Aggregate carrying value as of the balance sheet date of the liabilities for stock option plans and other equity-based compensation arrangements.

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Amount of cost to be recognized for nonvested award under share-based payment arrangement. Excludes share and unit options.

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Amount of cost to be recognized for option under share-based payment arrangement.

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The cash outflow for cost incurred directly with the issuance of an equity security.

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Face amount or stated value per share of preferred stock nonredeemable or redeemable solely at the option of the issuer.

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Fair value of share-based awards for which the grantee gained the right by satisfying service and performance requirements, to receive or retain shares or units, other instruments, or cash.

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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Stockholders' Equity - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands							1 Months Ended		3 Months Ended	12 Months Ended
	Aug. 16, 2024	Aug. 09, 2024	Jun. 17, 2024	Mar. 04, 2024	Nov. 27, 2023	Nov. 08, 2022	Nov. 30, 2023	Jun. 30, 2020	Mar. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Jun. 16, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock, shares authorized (in shares)										400,000,000	400,000,000		400,000,000
Preferred stock, shares authorized (in shares)													40,000,000
Common stock, par value (in dollars per share)										$ 0.0001	$ 0.0001		$ 0.0001
Preferred stock, par value (in dollars per share)													$ 0.0001
Preferred stock, shares outstanding (in shares)										0	0	0
Proceeds from issuance of common stock in public offerings, net of issuance costs										$ 762,161	$ 60,547	$ 344,779
Award vesting period										4 years
Total stock-based compensation expense										$ 51,363	38,222	27,139
Expected dividend yield										0.00%
Unrecognized compensation cost, options										$ 102,500
Forecast
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
PSUs vested (in shares)									187,500
Restricted stock units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense										$ 7,000	$ 900	$ 0
PSUs vested (in shares)										184,293	0	0
Fair value of shares vested during the period										$ 3,500
Granted (in shares)										1,711,000
Unrecognized compensation cost, excluding options										$ 45,200
Performance Stock Units (PSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense										$ 4,800	$ 0	$ 0
PSUs vested (in shares)										562,500	0	0
Fair value of shares vested during the period										$ 22,100
Outstanding PSUs (in shares)										750,000
Granted (in shares)										738,000
Unrecognized compensation cost, excluding options										$ 32,100
Unrecognized compensation cost, probable amount										$ 200
Employee Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares available for grant (in shares)										193,367
Participant maximum contribution as percentage of eligible compensation								15.00%
Award offering period								6 months		6 months
Percentage of purchase price of shares of lower of fair market value								85.00%
Issuance of common stock under employee stock purchase plan (in shares)										179,150	175,511	90,535
Outstanding liability										$ 300
Expected dividend yield										0.00%	0.00%	0.00%
Unrecognized compensation cost, excluding options										$ 900
Weighted-average period of unrecognized compensation cost										6 months
Common stock options issued and outstanding
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected dividend yield										0.00%	0.00%	0.00%
Weighted-average period of unrecognized compensation cost										2 years 8 months 12 days
Weighted Average \| Restricted stock units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average period of unrecognized compensation cost										3 years 2 months 12 days
Weighted Average \| Performance Stock Units (PSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average period of unrecognized compensation cost										2 months 12 days
2020 Incentive Award Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares of common stock reserved for future issuance (in shares)								3,900,000
Percentage of shares of common stock outstanding on final day of immediately preceding calendar year								5.00%
Shares available for grant (in shares)										1,591,462
Additional shares reserved for future issuance (in shares)										3,963,742
2020 Incentive Award Plan \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expiration period										10 years
2022 Employment Inducement Incentive Award Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares of common stock reserved for future issuance (in shares)												4,500,000
Shares available for grant (in shares)										697,350
Additional shares reserved for future issuance (in shares)										3,000,000
2022 Employment Inducement Incentive Award Plan \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expiration period										10 years
2013 Equity Incentive Plan \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expiration period										10 years
Pre-Funded Common Stock Warrant
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Class of warrant or right, exercise price (in dollar per share)										$ 0.001
Research Collaboration, License Agreement and Securities Purchase Agreement with BMS
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of stock, consideration received on transaction							$ 40,000
Private Placement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Public offering issuance costs										$ 12,821	$ 74
Issuance of common stock, net of issuance costs										238,388	31,190
Private Placement \| Research Collaboration, License Agreement and Securities Purchase Agreement with BMS
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of stock number of shares issued in transaction (in shares)					5,075,304		5,075,304
Public offering issuance costs					$ 100
Sale of stock, consideration received on transaction					40,000		$ 40,000
Issuance of common stock, net of issuance costs					31,200
Premium In excess of fair value					$ 8,700		$ 8,700
Sale of stock, price per share (in dollars per share)							$ 7.8813
Private Placement Offering 2024
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of stock number of shares issued in transaction (in shares)				15,224,773
Sale of stock, consideration received on transaction				$ 379,800
Sale of stock, price per share (in dollars per share)				$ 16.50
Payments of stock issuance costs				$ 20,400
Private Placement Offering 2024 \| Principal Owner
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of stock number of shares issued in transaction (in shares)				2,121,213
Sale of stock, consideration received on transaction				$ 35,000
Private Placement Offering 2024 \| Pre-Funded Common Stock Warrant
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Class of warrant or right, number of securities called by warrants or rights (in shares)				9,030,851
Sale of stock, price per share (in dollars per share)				$ 16.499
Class of warrant or right, exercise price (in dollar per share)				$ 0.001
Public Stock Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of stock number of shares issued in transaction (in shares)	8,418,000		12,132,500
Public offering issuance costs										49,749	1,385	$ 18,230
Sale of stock, consideration received on transaction	$ 323,700		$ 432,800
Issuance of common stock, net of issuance costs										$ 762,161	$ 60,547	$ 344,616
Sale of stock, price per share (in dollars per share)	$ 41.00		$ 38.00
Payments of stock issuance costs	$ 21,400		$ 28,300
Sales Agent \| Private Placement, 2022 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of common stock maximum aggregate offering price						$ 200,000
Sales Agent \| Private Placement, 2021 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of stock number of shares issued in transaction (in shares)										418,408	4,107,810
Proceeds from issuance of common stock in public offerings, net of issuance costs										$ 5,600	$ 60,500
Public offering issuance costs										$ 100	$ 1,400
TD Securities (USA), LLC \| Private Placement 2024 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sale of stock number of shares issued in transaction (in shares)										0
Sale of common stock maximum aggregate offering price		$ 400,000