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Consolidated Statements of Stockholders’ Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Public Stock Offering
Private Placement
Pre Funded Warrants Private Placement
Common Stock
Common Stock
Public Stock Offering
Common Stock
Private Placement
Additional Paid-in Capital
Additional Paid-in Capital
Public Stock Offering
Additional Paid-in Capital
Private Placement
Additional Paid-in Capital
Pre Funded Warrants Private Placement
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021         47,754                
Beginning balance at Dec. 31, 2021 $ 381,430       $ 5     $ 566,161       $ (187) $ (184,549)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                          
Issuance of common stock, net of issuance costs (in shares)           21,572              
Issuance of common stock, net of issuance costs   $ 344,616       $ 2     $ 344,614        
Issuance of common stock upon exercise of stock options (in shares)         351                
Issuance of common stock upon exercise of stock options 470             470          
Issuance of common stock under employee stock purchase plan (in shares)         91                
Issuance of common stock under employee stock purchase plan 922             922          
Vesting of early exercise options 4             4          
Stock-based compensation 27,139             27,139          
Net loss (173,995)                       (173,995)
Other comprehensive loss (income) (2,511)                     (2,511)  
Ending balance (in shares) at Dec. 31, 2022         69,768                
Ending balance at Dec. 31, 2022 578,075       $ 7     939,310       (2,698) (358,544)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                          
Issuance of common stock, net of issuance costs (in shares)           4,107 5,075            
Issuance of common stock, net of issuance costs   60,547 $ 31,190       $ 1   60,547 $ 31,189      
Issuance of common stock upon exercise of stock options (in shares)         149                
Issuance of common stock upon exercise of stock options 573             573          
Issuance of common stock under employee stock purchase plan (in shares)         176                
Issuance of common stock under employee stock purchase plan 1,554             1,554          
Stock-based compensation 38,222             38,222          
Net loss (212,220)                       (212,220)
Other comprehensive loss (income) $ 2,823                     2,823  
Ending balance (in shares) at Dec. 31, 2023 79,275       79,275                
Ending balance at Dec. 31, 2023 $ 500,764       $ 8     1,071,395       125 (570,764)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                          
Issuance of common stock, net of issuance costs (in shares)           20,969 15,225            
Issuance of common stock, net of issuance costs   $ 762,161 $ 238,388 $ 141,395   $ 2 $ 2   $ 762,159 $ 238,386 $ 141,395    
Issuance of common stock upon exercise of stock options (in shares) 3,498       3,498                
Issuance of common stock upon exercise of stock options $ 48,204             48,204          
Issuance of common stock under employee stock purchase plan (in shares)         179                
Issuance of common stock under employee stock purchase plan 2,209             2,209          
Issuance of common stock in connection with vesting of restricted stock units (in shares)         747                
Stock-based compensation 51,363             51,363          
Net loss (322,302)                       (322,302)
Other comprehensive loss (income) $ 2,777                     2,777  
Ending balance (in shares) at Dec. 31, 2024 119,893       119,893                
Ending balance at Dec. 31, 2024 $ 1,424,959       $ 12     $ 2,315,111       $ 2,902 $ (893,066)