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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities:    
Net loss $ (25,192) $ (17,549)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 5,371 2,205
Net amortization (accretion) of premiums (discounts) on marketable securities (2,538) 276
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (3) 778
Other assets (228) 630
Accounts payable (672) 1,353
Accrued expenses (1,152) (1,235)
Net cash used in operating activities (24,414) (13,542)
Cash flows from investing activities:    
Purchases of marketable securities (187,948) (13,943)
Proceeds from sales and maturities of marketable securities 60,688 27,000
Net cash provided by (used in) investing activities (127,260) 13,057
Cash flows from financing activities:    
Payments of insurance costs financed by a third-party (546) (781)
Proceeds from issuance of common stock upon option exercise 619 13
Payments of offering costs (90)  
Net cash used in financing activities (17) (768)
Net decrease in cash and cash equivalents (151,691) (1,253)
Cash and cash equivalents at beginning of period 241,806 68,526
Cash and cash equivalents at end of period $ 90,115 $ 67,273