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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2024 | Sep. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (185,993) | $ (87,927)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation expense | 44,441 | 18,073
Net accretion on marketable securities | (9,736) | (8,017)
Change in fair value of related party revenue share liability | 16,600 | 0
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (4,783) | 712
Other assets | (3,287) | (839)
Accounts payable | 6,580 | 2,676
Accrued expenses | 13,114 | 5,792
Net cash used in operating activities | (123,064) | (69,530)
Cash flows from investing activities: |  |
Purchases of marketable securities | (712,468) | (292,764)
Proceeds from maturities and sales of marketable securities | 308,999 | 205,498
Net cash used in investing activities | (403,469) | (87,266)
Cash flows from financing activities: |  |
Proceeds from issuance of common stock, net | 561,200 | 3,669
Payments of equity issuance costs | (188) | (90)
Payments of insurance costs financed by a third-party | (622) | (155)
Net cash provided by financing activities | 560,390 | 3,424
Net increase (decrease) in cash and cash equivalents | 33,857 | (153,372)
Cash and cash equivalents at beginning of period | 335,387 | 241,806
Cash and cash equivalents at end of period | 369,244 | 88,434
Supplemental disclosure of noncash financing information: |  |
Equity issuance costs | 237 | 0
Insurance premium financed by a third-party | $ 0 | $ 1,399,000

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