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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Federal statutory income tax rate | $ (89,206) |  |
Federal statutory income tax rate, percent | 21.00% | 21.00% | 21.00%
State income taxes, net of federal (national) income tax effect | $ 585 |  |
State income taxes, net of federal (national) income tax effect, percent | (0.10%) | 6.70% | 8.30%
Foreign tax effects | $ 0 |  |
Foreign tax effects, percent | 0.00% |  |
Effect of changes in tax laws or rates enacted in the current period | $ 0 |  |
Effect of changes in tax laws or rates enacted in the current period, percent | 0.00% |  |
Effect of cross-border tax laws | $ 0 |  |
Effect of cross-border tax laws, percent | 0.00% |  |
Orphan drug related tax credits | $ (27,137) |  |
Orphan drug related tax credits, percent | 6.40% |  |
R&D tax credit | $ 1,061 |  |
R&D tax credit, percent | (0.30%) |  |
Tax credits generated |  | 14.30% | 5.70%
Changes in valuation allowances | $ 114,819 |  |
Changes in valuation allowances, percent | (27.00%) | (45.80%) | (38.70%)
Nontaxable or nondeductible items, Section 162(m) limitation | $ 12,316 |  |
Nontaxable or nondeductible items, Section 162(m) limitation, percent | (2.90%) |  |
Nontaxable or nondeductible items, stock-based compensation | $ (12,413) |  |
Nontaxable or nondeductible items, stock-based compensation, percent | 2.90% | 3.60% | 3.50%
Nontaxable or nondeductible items, permanent adjustments | $ 113 |  |
Nontaxable or nondeductible items, permanent adjustments, percent | 0.00% |  |
Changes in unrecognized tax benefits | $ 0 |  |
Changes in unrecognized tax benefits, percent | 0.00% |  |
Other adjustments | $ 447 |  |
Other adjustments, percent | (0.10%) |  |
Other |  | (0.10%) | 0.20%
Effective income tax rate | $ 585 | $ 764 | $ 0
Effective income tax rate, percent | (0.10%) | (0.30%) | 0.00%

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