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v3.25.4

Segment Information - Schedule of Segment Information (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Segment Reporting Information [Line Items] |  |  |  |
Personnel-related expenses |  | $ 73,163 | $ 44,121 | $ 29,225
Stock-based compensation expense |  | 86,502 | 60,579 | 25,563
Change in fair value of related party revenue share liability |  | 55,220 | 17,940 | 0
Interest income |  | (44,794) | (38,372) | (23,277)
Other segment items | [1] | 41,009 | 17,511 | 9,293
Income tax provision |  | 585 | 764 | 0
Net loss |  | (425,377) | (260,756) | (126,219)
Zidesamtinib [Member] |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Direct external expenses by program |  | 59,519 | 62,110 | 27,878
Neladalkib [Member] |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Direct external expenses by program |  | 105,446 | 67,778 | 31,894
NVL-330 [Member] |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Direct external expenses by program |  | 21,819 | 8,293 | 10,634
Discovery Programs [Member] |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Direct external expenses by program |  | 11,875 | 9,178 | 8,586
General and Administrative Expenses [Member] |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Stock-based compensation expense |  | 38,405 | 29,210 | 13,963
General and administrative professional and consultant fees |  | $ 15,033 | $ 10,854 | $ 6,423
[1] | Other segment items included in consolidated net loss include expenses for commercialization preparation activities, research and development consulting services, information technology, insurance, employee recruitment and other miscellaneous activities.

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