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Segment Information | 12 Months Ended
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Dec. 31, 2025
Segment Reporting [Abstract] |
Segment Information | 11. Segment Information The Company is a clinical-stage biopharmaceutical company and has not generated any revenue since commencing significant operations in 2018. The Company’s operations are organized and reported as one reportable segment, which includes all activities related to the discovery, development, and commercialization of precisely targeted therapies for patients with cancer. This presentation is consistent with how the Company’s chief operating decision maker (“CODM”), its Chief Executive Officer, assesses the performance of the Company and makes operating decisions on a consolidated basis. The accounting policies of the consolidated segment are the same as those described in the summary of significant accounting policies (see Note 2). The CODM assesses performance and decides how to allocate resources based on consolidated net loss as reported on the consolidated statements of operations and comprehensive loss. The CODM uses consolidated net loss to monitor budget versus actual results, assess cash runway, and benchmark against the Company’s competitors. The measure of segment assets is reported on the consolidated balance sheets as total assets. The Company’s assets are held in the United States. The following table sets forth the Company’s segment information (in thousands):
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |  |  | 2023 |
Direct external expenses by program: |  |  |  |  |  |  |  |  |
Zidesamtinib |  | $ | 59,519 |  |  | $ | 62,110 |  |  | $ | 27,878 |
Neladalkib |  |  | 105,446 |  |  |  | 67,778 |  |  |  | 31,894 |
NVL-330 |  |  | 21,819 |  |  |  | 8,293 |  |  |  | 10,634 |
Discovery programs |  |  | 11,875 |  |  |  | 9,178 |  |  |  | 8,586 |
Personnel-related expenses |  |  | 73,163 |  |  |  | 44,121 |  |  |  | 29,225 |
Stock-based compensation expense |  |  | 86,502 |  |  |  | 60,579 |  |  |  | 25,563 |
General and administrative professional and consultant fees |  |  | 15,033 |  |  |  | 10,854 |  |  |  | 6,423 |
Change in fair value of related party revenue share liability |  |  | 55,220 |  |  |  | 17,940 |  |  |  | — |
Interest income |  |  | (44,794 | ) |  |  | (38,372 | ) |  |  | (23,277 | )
Other segment items(1) |  |  | 41,009 |  |  |  | 17,511 |  |  |  | 9,293 |
Income tax provision |  |  | 585 |  |  |  | 764 |  |  |  | — |
Consolidated net loss |  | $ | (425,377 | ) |  | $ | (260,756 | ) |  | $ | (126,219 | )
(1) Other segment items included in consolidated net loss include expenses for commercialization preparation activities, research and development consulting services, information technology, insurance, employee recruitment and other miscellaneous activities.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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