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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Income tax provisions | $ 585,000 | $ 764,000 | $ 0
Federal statutory income tax rate, percent | 21.00% | 21.00% | 21.00%
Unrecognized Tax Benefits | $ 0 | $ 0 |
Description of income tax examination | In the normal course of business, the Company is subject to examination by federal and state jurisdictions, where applicable. There are currently no pending tax examinations. The Company is open to future tax examination under statute from 2022 to the present. |  |
Research and development tax credit carryforward expiration year start | 2033 |  |
Increased valuation allowance | $ 142,500,000 | 119,100,000 | $ 48,800,000
Open tax year | 2022 2023 2024 2025 |  |
Research Tax Credit Carryforward [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Income tax provisions | $ 0 | 0 | 0
Net Operating Losses [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Income tax provisions | 0 | $ 0 | $ 0
State and Local Jurisdiction [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Operating loss carryforwards | $ 531,100,000 |  |
Operating loss carryforward expiration year start | 2037 |  |
State and Local Jurisdiction [Member] | Research Tax Credit Carryforward [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Tax credit carryforwards research and development | $ 14,100,000 |  |
Domestic Tax Authority [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Operating loss carryforwards | 503,200,000 |  |
Domestic Tax Authority [Member] | Research Tax Credit Carryforward [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Tax credit carryforwards research and development | 14,600,000 |  |
Domestic Tax Authority [Member] | Orphan Drug Credit [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Tax credit carryforwards research and development | 56,500,000 |  |
Domestic Tax Authority [Member] | Expirable [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Operating loss carryforwards | $ 1,200,000 |  |
Operating loss carryforward expiration year start | 2037 |  |
Domestic Tax Authority [Member] | Non expirable [Member] |  |  |
Effective Income Tax Rate Reconciliation [Line Items] |  |  |
Operating loss carryforwards | $ 502,000,000 |  |
Operating loss carryforward offset limit percentage | 80.00% |  |

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