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Income Taxes - Additional Information (Detail) - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Effective Income Tax Rate Reconciliation [Line Items]      
Income tax provisions $ 585,000 $ 764,000 $ 0
Federal statutory income tax rate, percent 21.00% 21.00% 21.00%
Unrecognized Tax Benefits $ 0 $ 0  
Description of income tax examination In the normal course of business, the Company is subject to examination by federal and state jurisdictions, where applicable. There are currently no pending tax examinations. The Company is open to future tax examination under statute from 2022 to the present.    
Research and development tax credit carryforward expiration year start 2033    
Increased valuation allowance $ 142,500,000 119,100,000 $ 48,800,000
Open tax year 2022 2023 2024 2025    
Research Tax Credit Carryforward [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Income tax provisions $ 0 0 0
Net Operating Losses [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Income tax provisions 0 $ 0 $ 0
State and Local Jurisdiction [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Operating loss carryforwards $ 531,100,000    
Operating loss carryforward expiration year start 2037    
State and Local Jurisdiction [Member] | Research Tax Credit Carryforward [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Tax credit carryforwards research and development $ 14,100,000    
Domestic Tax Authority [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Operating loss carryforwards 503,200,000    
Domestic Tax Authority [Member] | Research Tax Credit Carryforward [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Tax credit carryforwards research and development 14,600,000    
Domestic Tax Authority [Member] | Orphan Drug Credit [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Tax credit carryforwards research and development 56,500,000    
Domestic Tax Authority [Member] | Expirable [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Operating loss carryforwards $ 1,200,000    
Operating loss carryforward expiration year start 2037    
Domestic Tax Authority [Member] | Non expirable [Member]      
Effective Income Tax Rate Reconciliation [Line Items]      
Operating loss carryforwards $ 502,000,000    
Operating loss carryforward offset limit percentage 80.00%