XML 61 R48.htm IDEA: XBRL DOCUMENT v3.25.4
Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Effective Income Tax Rate Reconciliation [Line Items]      
Federal statutory income tax rate $ (89,206)    
Federal statutory income tax rate, percent 21.00% 21.00% 21.00%
State income taxes, net of federal (national) income tax effect $ 585    
State income taxes, net of federal (national) income tax effect, percent (0.10%) 6.70% 8.30%
Foreign tax effects $ 0    
Foreign tax effects, percent 0.00%    
Effect of changes in tax laws or rates enacted in the current period $ 0    
Effect of changes in tax laws or rates enacted in the current period, percent 0.00%    
Effect of cross-border tax laws $ 0    
Effect of cross-border tax laws, percent 0.00%    
Orphan drug related tax credits $ (27,137)    
Orphan drug related tax credits, percent 6.40%    
R&D tax credit $ 1,061    
R&D tax credit, percent (0.30%)    
Tax credits generated   14.30% 5.70%
Changes in valuation allowances $ 114,819    
Changes in valuation allowances, percent (27.00%) (45.80%) (38.70%)
Nontaxable or nondeductible items, Section 162(m) limitation $ 12,316    
Nontaxable or nondeductible items, Section 162(m) limitation, percent (2.90%)    
Nontaxable or nondeductible items, stock-based compensation $ (12,413)    
Nontaxable or nondeductible items, stock-based compensation, percent 2.90% 3.60% 3.50%
Nontaxable or nondeductible items, permanent adjustments $ 113    
Nontaxable or nondeductible items, permanent adjustments, percent 0.00%    
Changes in unrecognized tax benefits $ 0    
Changes in unrecognized tax benefits, percent 0.00%    
Other adjustments $ 447    
Other adjustments, percent (0.10%)    
Other   (0.10%) 0.20%
Effective income tax rate $ 585 $ 764 $ 0
Effective income tax rate, percent (0.10%) (0.30%) 0.00%