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Segment Information - Schedule of Segment Information (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Segment Reporting Information [Line Items]      
Personnel-related expenses $ 73,163 $ 44,121 $ 29,225
Stock-based compensation expense 86,502 60,579 25,563
Change in fair value of related party revenue share liability 55,220 17,940 0
Interest income (44,794) (38,372) (23,277)
Other segment items [1] 41,009 17,511 9,293
Income tax provision 585 764 0
Net loss (425,377) (260,756) (126,219)
Zidesamtinib [Member]      
Segment Reporting Information [Line Items]      
Direct external expenses by program 59,519 62,110 27,878
Neladalkib [Member]      
Segment Reporting Information [Line Items]      
Direct external expenses by program 105,446 67,778 31,894
NVL-330 [Member]      
Segment Reporting Information [Line Items]      
Direct external expenses by program 21,819 8,293 10,634
Discovery Programs [Member]      
Segment Reporting Information [Line Items]      
Direct external expenses by program 11,875 9,178 8,586
General and Administrative Expenses [Member]      
Segment Reporting Information [Line Items]      
Stock-based compensation expense 38,405 29,210 13,963
General and administrative professional and consultant fees $ 15,033 $ 10,854 $ 6,423
[1] Other segment items included in consolidated net loss include expenses for commercialization preparation activities, research and development consulting services, information technology, insurance, employee recruitment and other miscellaneous activities.