    <SEC-DOCUMENT>0000950170-23-013884-index.html : 20230421
    <SEC-HEADER>0000950170-23-013884.hdr.sgml : 20230421
    <ACCEPTANCE-DATETIME>20230421172409
    ACCESSION NUMBER:		0000950170-23-013884
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230421
    DATE AS OF CHANGE:		20230421
    EFFECTIVENESS DATE:		20230421

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Axsome Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001579428
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				454241907
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-37635
    		FILM NUMBER:		23837371

    	BUSINESS ADDRESS:
    		STREET 1:		ONE WORLD TRADE CENTER, 22ND FLOOR
    		CITY:			NEW YORK
    		STATE:			NY
    		ZIP:			10007
    		BUSINESS PHONE:		(212) 332-3241

    	MAIL ADDRESS:
    		STREET 1:		ONE WORLD TRADE CENTER, 22ND FLOOR
    		CITY:			NEW YORK
    		STATE:			NY
    		ZIP:			10007
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>annual_report_2022_pdf.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: annual_report_2022_pdf.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>