<SEC-DOCUMENT>0001921094-24-000384.txt : 20240314
<SEC-HEADER>0001921094-24-000384.hdr.sgml : 20240314
<ACCEPTANCE-DATETIME>20240314162008
ACCESSION NUMBER:		0001921094-24-000384
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20240314
DATE AS OF CHANGE:		20240314

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Axsome Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001579428
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				454241907
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-37635
		FILM NUMBER:		24750446

	BUSINESS ADDRESS:	
		STREET 1:		ONE WORLD TRADE CENTER, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10007
		BUSINESS PHONE:		(212) 332-3241

	MAIL ADDRESS:	
		STREET 1:		ONE WORLD TRADE CENTER, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10007

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			JEFFS ROGER
		CENTRAL INDEX KEY:			0001231615
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <filer>
        <filerCredentials>
          <cik>0001231615</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001579428</issuerCik>
      <issuerName>Axsome Therapeutics, Inc.</issuerName>
      <secFileNumber>001-37635</secFileNumber>
      <issuerAddress>
        <com:street1>ONE WORLD TRADE CENTER, 22ND FLOOR</com:street1>
        <com:city>NEW YORK</com:city>
        <com:stateOrCountry>NY</com:stateOrCountry>
        <com:zipCode>10007</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(212) 332-3241</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JEFFS ROGER</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>29976</noOfUnitsSold>
      <aggregateMarketValue>2089386.00</aggregateMarketValue>
      <noOfUnitsOutstanding>47374375</noOfUnitsOutstanding>
      <approxSaleDate>03/14/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/14/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Axsome Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>29976</amountOfSecuritiesAcquired>
      <paymentDate>03/14/2024</paymentDate>
      <natureOfPayment>Broker Payment for Cashless Exercise</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>03/14/2024</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>12/14/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>ROGER JEFFS</signature>
    </noticeSignature>
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