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Condensed Consolidated Statement of Operations and Comprehensive Loss - USD ($)
$ in Thousands

3 Months Ended

9 Months Ended

Sep. 30, 2017

Sep. 30, 2016

Sep. 30, 2017

Sep. 30, 2016

Income Statement [Abstract]

Collaboration revenue

^[1]

$ 2,387

$ 1,549

$ 8,672

$ 2,820

Operating expenses:

Research and development

^[2]

17,845

12,052

49,770

26,666

General and administrative

8,112

4,107

24,522

18,974

Total operating expenses

25,957

16,159

74,292

45,640

Loss from operations

(23,570)

(14,610)

(65,620)

(42,820)

Other (expense) income:

Interest expense

(1)

(8,051)

Loss from equity method investment

(359)

(1,310)

(686)

Gain on extinguishment of convertible loan

11,482

Other expense, net

(71)

(75)

(238)

(141)

Total other (expense) income, net

(430)

(76)

(1,548)

2,604

Net loss before income taxes

(24,000)

(14,686)

(67,168)

(40,216)

Provision for income taxes

(707)

(8)

(1,330)

(84)

Net loss

(24,707)

(14,694)

(68,498)

(40,300)

Foreign currency translation adjustment

8

(1)

38

(18)

Comprehensive loss

(24,699)

(14,695)

(68,460)

(40,318)

Reconciliation of net loss to net loss attributable to common shareholders:

Net loss

(24,707)

(14,694)

(68,498)

(40,300)

Loss attributable to noncontrolling interest

14

24

Net loss attributable to common shareholders

$ (24,707)

$ (14,680)

$ (68,498)

$ (40,276)

Net loss per share attributable to common shareholders—basic and diluted

$ (0.62)

$ (2.77)

$ (1.72)

$ (7.43)

Weighted-average common shares outstanding used in net loss per share attributable to common shareholders—basic and diluted

40,088,718

5,292,348

39,904,863

5,422,617

[1]	Including the following revenue from a related party, see Note 11:
[2]	Including the following research and development expense with a related party, See Note 11:

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