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Related Party Transactions - Additional Information (Detail) - USD ($)		3 Months Ended		9 Months Ended
		Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016	Dec. 31, 2016
Related Party Transaction [Line Items]
Research and development expense	[1]	$ 17,845,000	$ 12,052,000	$ 49,770,000	$ 26,666,000
Accounts receivable, related party amount, current		1,133,000		1,133,000		$ 752,000
Other current assets, related party amount		583,000		583,000		0
Deferred revenue related party amount		171,000		171,000		527,000
Casebia Therapeutics LLP [Member]
Related Party Transaction [Line Items]
Revenue from collaboration agreement		1,200,000	400,000	3,900,000	400,000
Research and development expense		1,200,000	400,000	3,700,000	400,000
Bayer Healthcare LLC [Member]
Related Party Transaction [Line Items]
Sublicense fees payable		0		0		500,000
Bayer Healthcare LLC [Member] | Casebia Therapeutics LLP [Member]
Related Party Transaction [Line Items]
Revenue from collaboration agreement		1,200,000	400,000	3,900,000	400,000
Research and development expense		1,200,000	400,000	3,700,000	400,000
Research and development expenses reimbursed		900,000		1,600,000
Accounts receivable, related party amount, current		1,100,000		1,100,000		800,000
Other current assets, related party amount		600,000		600,000		0
Deferred revenue related party amount		200,000		200,000		$ 500,000
Bayer Healthcare LLC [Member] | Research and Development [Member]
Related Party Transaction [Line Items]
Sublicense fees recorded		$ 0	$ 17,000	$ 0	$ 1,000,000
[1] Including the following research and development expense with a related party, See Note 11:

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