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Condensed Consolidated Statements of Shareholders' Equity - USD ($)
$ in Thousands
Total
Common Shares [Member]
Treasury Shares [Member]
Additional Paid-in Capital [Member]
Accumulated Deficit [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Beginning balance at Dec. 31, 2018 $ 392,195 $ 1,584 $ (57) $ 682,245 $ (291,569) $ (8)
Beginning balance (in shares) at Dec. 31, 2018   51,852,862 307,936      
Issuance of common shares, net of issuance costs 23,472     23,472    
Issuance of common shares, net of issuance costs (in shares)   631,580        
Vesting of restricted shares 15     15    
Vesting of restricted shares (in shares)   9,288        
Exercise of vested options, value 1,832 $ 5   1,827    
Exercise of vested options (in shares)   141,915        
Stock-based compensation expense 10,696     10,696    
Other comprehensive income (loss) 8         8
Net income (loss) (48,408)       (48,408)  
Ending balance at Mar. 31, 2019 379,810 $ 1,589 $ (57) 718,255 (339,977)  
Ending balance (in shares) at Mar. 31, 2019   52,635,645 307,936      
Beginning balance at Dec. 31, 2018 392,195 $ 1,584 $ (57) 682,245 (291,569) (8)
Beginning balance (in shares) at Dec. 31, 2018   51,852,862 307,936      
Net income (loss) 36,316          
Ending balance at Sep. 30, 2019 591,878 $ 1,684 $ (57) 845,526 (255,253) (22)
Ending balance (in shares) at Sep. 30, 2019   55,189,370 256,989      
Beginning balance at Dec. 31, 2018 392,195 $ 1,584 $ (57) 682,245 (291,569) (8)
Beginning balance (in shares) at Dec. 31, 2018   51,852,862 307,936      
Ending balance at Dec. 31, 2019 939,425 $ 1,847 $ (63) 1,162,345 (224,711) 7
Ending balance (in shares) at Dec. 31, 2019   60,783,799 250,226      
Beginning balance at Mar. 31, 2019 379,810 $ 1,589 $ (57) 718,255 (339,977)  
Beginning balance (in shares) at Mar. 31, 2019   52,635,645 307,936      
Issuance of common shares, net of issuance costs 28,114 $ 40   28,074    
Issuance of common shares, net of issuance costs (in shares)   732,108 (47,297)      
Vesting of restricted shares 16 $ 1   15    
Vesting of restricted shares (in shares)   12,317        
Exercise of vested options, value 1,254     1,254    
Exercise of vested options (in shares)   118,987 (3,650)      
Stock-based compensation expense 12,198     12,198    
Other comprehensive income (loss) (10)         (10)
Net income (loss) (53,699)       (53,699)  
Ending balance at Jun. 30, 2019 367,683 $ 1,630 $ (57) 759,796 (393,676) (10)
Ending balance (in shares) at Jun. 30, 2019   53,499,057 256,989      
Issuance of common shares, net of issuance costs 68,661 $ 43   68,618    
Issuance of common shares, net of issuance costs (in shares)   1,452,880        
Vesting of restricted shares 12 $ 1   11    
Vesting of restricted shares (in shares)   34,328        
Exercise of vested options, value 2,338 $ 10   2,328    
Exercise of vested options (in shares)   203,105        
Stock-based compensation expense 14,773     14,773    
Other comprehensive income (loss) (12)         (12)
Net income (loss) 138,423       138,423  
Ending balance at Sep. 30, 2019 591,878 $ 1,684 $ (57) 845,526 (255,253) (22)
Ending balance (in shares) at Sep. 30, 2019   55,189,370 256,989      
Beginning balance at Dec. 31, 2019 939,425 $ 1,847 $ (63) 1,162,345 (224,711) 7
Beginning balance (in shares) at Dec. 31, 2019   60,783,799 250,226      
Vesting of restricted shares (in shares)   5,000        
Exercise of vested options, value 1,388 $ 3   1,385    
Exercise of vested options (in shares)   83,406        
Stock-based compensation expense 14,151     14,151    
Issuance of common shares related to license agreement 889     889    
Issuance of common shares related to license agreement (in shares)   17,830 (17,830)      
Other comprehensive income (loss) (25)         (25)
Net income (loss) (69,731)       (69,731)  
Ending balance at Mar. 31, 2020 886,097 $ 1,850 $ (63) 1,178,770 (294,442) (18)
Ending balance (in shares) at Mar. 31, 2020   60,890,035 232,396      
Beginning balance at Dec. 31, 2019 $ 939,425 $ 1,847 $ (63) 1,162,345 (224,711) 7
Beginning balance (in shares) at Dec. 31, 2019   60,783,799 250,226      
Exercise of vested options (in shares) 1,011,236          
Net income (loss) $ (241,826)          
Ending balance at Sep. 30, 2020 1,343,301 $ 2,157 $ (63) 1,807,878 (466,537) (134)
Ending balance (in shares) at Sep. 30, 2020   70,603,862 195,316      
Beginning balance at Mar. 31, 2020 886,097 $ 1,850 $ (63) 1,178,770 (294,442) (18)
Beginning balance (in shares) at Mar. 31, 2020   60,890,035 232,396      
Issuance of common shares, net of issuance costs 82,189 $ 38   82,151    
Issuance of common shares, net of issuance costs (in shares)   1,238,453        
Vesting of restricted shares 1 $ 1        
Vesting of restricted shares (in shares)   29,916        
Exercise of vested options, value 6,345 $ 11   6,334    
Exercise of vested options (in shares)   394,101 (37,080)      
Stock-based compensation expense 15,697     15,697    
Other comprehensive income (loss) (3)         (3)
Net income (loss) (79,656)       (79,656)  
Ending balance at Jun. 30, 2020 910,670 $ 1,900 $ (63) 1,282,952 (374,098) (21)
Ending balance (in shares) at Jun. 30, 2020   62,552,505 195,316      
Issuance of common shares, net of issuance costs 494,589 $ 240   494,349    
Issuance of common shares, net of issuance costs (in shares)   7,499,135        
Vesting of restricted shares 1 $ 1        
Vesting of restricted shares (in shares)   39,667        
Exercise of vested options, value 12,659 $ 16   12,643    
Exercise of vested options (in shares)   499,145        
Purchase of common stock under ESPP 694     694    
Purchase of common stock under ESPP (in shares)   13,410        
Stock-based compensation expense 17,240     17,240    
Other comprehensive income (loss) (113)         (113)
Net income (loss) (92,439)       (92,439)  
Ending balance at Sep. 30, 2020 $ 1,343,301 $ 2,157 $ (63) $ 1,807,878 $ (466,537) $ (134)
Ending balance (in shares) at Sep. 30, 2020   70,603,862 195,316