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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Operating activities:    
Net loss $ (241,826) $ 36,316
Reconciliation of net loss to net cash used in operating activities:    
Depreciation and amortization 6,618 3,293
Equity-based compensation 47,088 32,200
Loss from equity method investment   5,467
Other expense, non-cash 979  
Changes in:    
Accounts receivable (11) 49
Prepaid expenses and other assets 19,273 (25,342)
Accounts payable and accrued expenses 17,394 420
Deferred revenue (350) 1,714
Operating lease assets and liabilities (282) (689)
Other liabilities, net (6,037) (127)
Net cash (used in) provided by operating activities (157,154) 53,301
Investing activities:    
Purchase of property, plant and equipment (12,119) (5,732)
Purchases of marketable securities (325,316)  
Maturities of marketable securities 509  
Net cash used in investing activities (336,926) (5,732)
Financing activities:    
Proceeds from issuance of common shares, net of issuance costs 582,225 121,216
Proceeds from exercise of options and ESPP contributions, net of issuance costs 21,300 5,049
Net cash provided by financing activities 603,525 126,265
Effect of exchange rate changes on cash 5 (14)
Increase in cash 109,450 173,820
Cash, cash equivalents and restricted cash, beginning of period 948,812 459,812
Cash, cash equivalents and restricted cash, end of period 1,058,262 633,632
Supplemental disclosure of non-cash investing and financing activities    
Property and equipment purchases in accounts payable and accrued expenses 2,863 428
Equity issuance costs in accounts payable and accrued expenses $ 5,955 $ 739