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Consolidated Statements of Operations and Comprehensive (Loss) Income - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenue:      
Total revenue $ 719 $ 289,590 $ 3,124
Operating expenses:      
Research and development [1] 266,946 179,362 113,773
General and administrative 88,208 63,488 48,294
Total operating expenses 355,154 242,850 162,067
(Loss) income from operations (354,435) 46,740 (158,943)
Other income (expense):      
Loss from equity method investment   (5,467) (4,275)
Other income (expense), net 6,379 26,033 (1,210)
Total other income (expense), net 6,379 20,566 (5,485)
Net (loss) income before income taxes (348,056) 67,306 (164,428)
Provision for income taxes (809) (448) (553)
Net (loss) income (348,865) 66,858 (164,981)
Foreign currency translation adjustment 40 15 (22)
Unrealized loss on marketable securities (130)    
Comprehensive (loss) income $ (348,955) $ 66,873 $ (165,003)
Net (loss) income per common share — basic $ (5.29) $ 1.23 $ (3.44)
Basic weighted-average common shares outstanding 65,949,672 54,392,304 47,964,368
Net (loss) income per common share — diluted $ (5.29) $ 1.17 $ (3.44)
Diluted weighted-average common shares outstanding 65,949,672 56,932,798 47,964,368
Collaboration Revenue [Member]      
Revenue:      
Total revenue [2] $ 543 $ 289,590 $ 3,124
Grant Revenue [Member]      
Revenue:      
Total revenue $ 176    
[1] Including the following amounts of research and development from a related party, see Note 9
[2] Including the following amounts of revenue from a related party, see Note 9