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Stock-based Compensation - Schedule of Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2021 | Mar. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Stock-based compensation expense | $ 22,092 | $ 14,151
Research and Development [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Stock-based compensation expense | 12,845 | 7,362
General and Administrative [Member] |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Stock-based compensation expense | $ 9,247 | $ 6,789

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