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Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Millions | 1 Months Ended |
--- | --- | ---
Jul. 31, 2020 | Nov. 30, 2019 | Mar. 31, 2021
Contingencies And Commitments [Line Items] |  |  |
Rental payments period | 152 months | 5 years |
Letter of Credit [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Letters of credit secured by cash held in restricted depository account |  |  | $ 16.8
Lease Arrangement [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Annual rental payments |  | $ 3.9 |
Lease Arrangement [Member] | Minimum [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Rental payments | $ 292.5 |  |
2015 Collaboration Agreement [Member] | Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Milestone payment receivable |  |  | $ 395.0

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