XML 42 R28.htm IDEA: XBRL DOCUMENT
v3.21.1

Stock-based Compensation (Tables) | 3 Months Ended
--- | ---
Mar. 31, 2021
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Schedule of Stock-Based Compensation Expense | During the three months ended March 31, 2021, the Company recognized the following stock-based compensation expense (in thousands):
|  | Three Months Ended March 31, |
|  | 2021 |  |  | 2020 |
Research and development |  | $ | 12,845 |  |  | $ | 7,362 |
General and administrative |  |  | 9,247 |  |  |  | 6,789 |
Total |  | $ | 22,092 |  |  | $ | 14,151 |
Summary of Stock Option Activity | The following table summarizes stock option activity for the three months ended March 31, 2021:
|  | Shares |  |  | Weighted- average exercise price per share |
Outstanding at December 31, 2020 |  |  | 8,101,980 |  |  | $ | 42.44 |
Granted |  |  | 882,558 |  |  |  | 139.05 |
Exercised |  |  | (342,471 | ) |  |  | 33.12 |
Cancelled or forfeited |  |  | (69,404 | ) |  |  | 43.31 |
Outstanding at March 31, 2021 |  |  | 8,572,663 |  |  | $ | 52.76 |
Exercisable at March 31, 2021 |  |  | 3,962,897 |  |  | $ | 31.48 |
Vested and expected to vest at March 31, 2021 |  |  | 8,572,663 |  |  | $ | 52.76 |
Summary of Restricted Stock Activity | The following table summarizes restricted stock activity for the three months ended March 31, 2021:
|  | Restricted Stock |  |  | Weighted- Average Grant Date Fair Value |
Unvested balance as of December 31, 2020 |  |  | 894,092 |  |  | $ | 70.55 |
Granted |  |  | 278,645 |  |  |  | 136.16 |
Vested |  |  | (109,355 | ) |  |  | 40.64 |
Cancelled or forfeited |  |  | (11,003 | ) |  |  | 57.94 |
Unvested balance as of March 31, 2021 |  |  | 1,052,379 |  |  | $ | 91.16 |

X
- References No definition available. + Details
Name: | us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5047-113901 + Details
Name: | us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock units. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
Name: | us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
Name: | us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration