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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating activities |  |  |
Net income (loss) | $ 377,661 | $ (348,865) | $ 66,858
Reconciliation of net income (loss) to net cash used in operating activities: |  |  |
Depreciation and amortization | 17,953 | 9,184 | 4,725
Equity-based compensation | 102,390 | 66,018 | 44,057
Loss from equity method investment in Casebia |  |  | 5,467
Gain from consolidation of Casebia |  |  | (16,000)
Net amortization of premiums and discounts on marketable securities | 14,109 | 1,857 |
Changes in: |  |  |
Accounts receivable | (161) | (45) | (11)
Prepaid expenses and other assets | (13,912) | 17,338 | (32,618)
Accounts payable and accrued expenses | 37,514 | 25,747 | 5,025
Deferred revenue | (783) | 1,381 | (45,146)
Operating lease assets and liabilities | 9,506 | (473) | (663)
Other liabilities, net | (5,305) | (10,508) | 24,983
Net cash provided by (used in) operating activities | 538,972 | (238,366) | 56,677
Investing activities |  |  |
Purchase of property, plant and equipment | (81,705) | (18,358) | (6,684)
Net cash and restricted cash received in connection with the acquisition of Casebia |  |  | 8,009
Purchases of marketable securities | (1,509,327) | (593,998) |
Maturities of marketable securities | 555,602 | 71,186 |
Net cash (used in) provided by investing activities | (1,035,430) | (541,170) | 1,325
Financing activities |  |  |
Proceeds from issuance of common shares, net of issuance costs | 213,267 | 982,289 | 415,019
Proceeds from exercise of options and ESPP contributions, net of issuance costs | 37,678 | 33,863 | 15,964
Net cash provided by financing activities | 250,945 | 1,016,152 | 430,983
Effect of exchange rate changes on cash | (11) | 40 | 15
(Decrease) increase in cash | (245,524) | 236,656 | 489,000
Cash, cash equivalents and restricted cash, beginning of period | 1,185,468 | 948,812 | 459,812
Cash, cash equivalents and restricted cash, end of period | 939,944 | 1,185,468 | 948,812
Supplemental disclosure of non-cash investing and financing activities |  |  |
Property and equipment purchases in accounts payable and accrued expenses | 8,348 | 3,412 | 1,811
Equity issuance costs in accounts payable and accrued expenses | $ 334 | $ 9,590 | $ 295

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