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Significant Contracts - Additional Information (Detail) |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  |  |  |  |
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Apr. 16, 2021 USD ($) | Dec. 13, 2019 USD ($) Product | Oct. 26, 2015 USD ($) | Dec. 31, 2021 USD ($) | Oct. 31, 2019 License | Dec. 31, 2019 USD ($) | Dec. 31, 2021 USD ($) Option | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Jul. 01, 2021 | Apr. 30, 2021 | Apr. 30, 2020 USD ($) | Dec. 12, 2019 | Mar. 31, 2016 | Feb. 12, 2016
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-current deferred revenue |  |  |  |  | $ 12,323,000 |  |  | $ 12,323,000 | $ 11,776,000 |  |  |  |  |  |  |
Current deferred revenue |  |  |  |  | $ 1,011,000 |  |  | 1,011,000 | 2,341,000 |  |  |  |  |  |  |
Research and development expense | [1] |  |  |  |  |  |  | $ 438,633,000 | 266,946,000 | $ 179,362,000 |  |  |  |  |  |
Date of joint venture agreement |  |  |  |  |  |  |  | Dec. 19, 2015 |  |  |  |  |  |  |  |
Operating expenses |  |  |  |  |  |  |  | $ 541,435,000 | 355,154,000 | 242,850,000 |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  |  | 102,390,000 | 66,018,000 | 49,524,000 |  |  |  |  |  |
Net loss of joint venture |  |  |  |  |  |  |  | 377,661,000 | (348,865,000) | 66,858,000 |  |  |  |  |  |
Issuance of common shares, value |  |  |  |  |  |  |  | 222,175,000 | 973,381,000 | 414,789,000 |  |  |  |  |  |
Proceeds from Issuance of Common Stock |  |  |  |  |  |  |  | 213,267,000 | 982,289,000 | 415,019,000 |  |  |  |  |  |
Other (expense) income |  |  |  |  |  |  |  | $ 6,003,000 | 6,379,000 | 26,033,000 |  |  |  |  |  |
Casebia Therapeutics Limited Liability Partnership [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Date of formation of joint venture entity |  |  |  |  |  |  |  | Feb. 12, 2016 |  |  |  |  |  |  |  |
Equity method investment, ownership percentage |  |  |  |  | 50.00% |  |  | 50.00% |  |  |  |  |  | 50.00% | 50.00% | 50.00%
Percentage of partnership interests |  |  | 100.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Partnership outstanding maximum exchange amount |  |  | $ 22,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Operating expenses |  |  | $ 6,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Number of products | Product |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of research and development costs |  |  | 50.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage sharing of profit (loss) from sale of product |  |  | 50.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable one-time option payment |  |  | $ 20,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Equity method investment |  |  |  |  | $ 0 |  |  | $ 0 |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  | 5,500,000 |  |  |  |  |  |
Unrecognized equity method losses in excess of Company's interest |  |  |  |  |  |  |  |  |  | 72,000,000.0 |  |  |  |  |  |
Business combination, consideration transferred |  |  |  |  |  |  |  | 41,000,000.0 |  |  |  |  |  |  |  |
Net assets acquired |  |  |  |  | 16,000,000.0 |  |  | 16,000,000.0 |  |  |  |  |  |  |  |
Fair value of assets and liabilities |  |  |  |  | 16,000,000.0 |  |  | 16,000,000.0 |  |  |  |  |  |  |  |
Payment to acquire business |  |  |  |  |  |  |  | $ 16,000,000.0 |  |  |  |  |  |  |  |
Number of options exercised under agreement | Option |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |
Casebia Therapeutics Limited Liability Partnership [Member] | Equity Method Investment, Nonconsolidated Investee or Group of Investees [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss of joint venture |  |  | $ 58,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  |  | $ 59,683,000 | 35,120,000 | 23,273,000 |  |  |  |  |  |
Research and Development Services [Member] | Casebia Therapeutics Limited Liability Partnership [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of obligations |  |  |  |  | 20,200,000 |  |  | 20,200,000 |  |  |  |  |  |  |  |
Future Delivery of up to Two Options [Member] | Casebia Therapeutics Limited Liability Partnership [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of obligations |  |  |  |  | 4,800,000 |  |  | 4,800,000 |  |  |  |  |  |  |  |
A&R Vertex JDCA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of net profits and net losses |  |  |  |  |  |  |  |  |  |  | 40.00% | 40.00% |  |  |  |
2019 Option Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  |  |  | 7,000,000.0 | 13,200,000 |  |  |  |  |  |  |
2019 Option Agreement [Member] | Casebia Therapeutics Limited Liability Partnership [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business combination, consideration transferred |  |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |
Fair value of controlling interest obtained |  |  |  |  |  |  |  | 32,000,000.0 |  |  |  |  |  |  |  |
Payment to acquire business |  |  |  |  |  |  |  | 16,000,000.0 |  |  |  |  |  |  |  |
2019 Option Agreement [Member] | Research and Development [Member] | Casebia Therapeutics Limited Liability Partnership [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business combination, consideration transferred |  |  |  |  |  |  |  | 20,200,000 |  |  |  |  |  |  |  |
2019 Option Agreement [Member] | Certain Options [Member] | Casebia Therapeutics Limited Liability Partnership [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business combination, consideration transferred |  |  |  |  |  |  |  | 4,800,000 |  |  |  |  |  |  |  |
2019 Casebia Agreement [Member] | Other Current Liabilities [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research obligation |  |  |  |  |  |  |  |  | 7,000,000.0 |  |  |  |  |  |  |
2019 Casebia Agreement [Member] | Other Long-term Liabilities [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research obligation |  |  |  |  | 4,800,000 |  |  | 4,800,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Nonrefundable upfront payment received |  |  |  | $ 75,000,000.0 |  |  |  | $ 175,000,000.0 |  |  |  |  |  |  |  |
Percentage of exchange payment of research and development costs |  |  |  |  |  |  |  | 50.00% |  |  |  |  |  |  |  |
Number of options would not be exercised under agreement | Option |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |
Number of remaining options under agreement | Option |  |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  |  |  | $ 268,600,000 |  |  |  |  |  |  |  |
Non-current deferred revenue |  |  |  |  | 12,300,000 |  |  | 12,300,000 | 11,800,000 |  |  |  |  |  |  |
Non-cash consideration received |  |  |  |  |  |  |  | 10,000,000.0 |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 12,300,000 |  |  | 12,300,000 |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  | 913,100,000 |  | 289,100,000 |  |  |  |  |  |
Current deferred revenue |  |  |  |  | 0.0 |  |  | 0.0 | 400,000 |  |  |  |  |  |  |
Collaboration revenue |  |  |  |  |  |  |  |  |  | 30,000,000.0 |  |  |  |  |  |
Maximum potential future payments |  |  |  |  |  |  |  | 775,000,000.0 |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  |  |  | 111,600,000 | 48,600,000 | 29,200,000 |  |  |  |  |  |
Reimbursements from research and license agreements |  |  |  |  |  |  |  | 47,400,000 | $ 28,200,000 | 15,900,000 |  |  |  |  |  |
Collaborative arrangement, license rights reacquired by waiving payment owed |  |  |  |  |  |  |  | 10,000,000.0 |  |  |  |  |  |  |  |
Non-cash consideration expensed upon execution of collaborative agreement |  |  |  |  |  |  |  | 10,000,000.0 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Research and Development [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Variable consideration received |  |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Collaboration Target Options [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment receivable |  |  |  |  | 420,000,000.0 |  |  | 420,000,000.0 |  |  |  |  |  |  |  |
Milestone payment receivable |  |  |  |  | 410,000,000.0 |  |  | 410,000,000.0 |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 46,700,000 |  |  | 46,700,000 |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 76,700,000 |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | DM1 R&D Services [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 1,700,000 |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 1,100,000 |  |  | 1,100,000 |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | DM1 R&D Services [Member] | Research and Development [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Variable consideration received |  |  |  |  |  |  |  | 800,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | DMD License [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 224,600,000 |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 151,100,000 |  |  | 151,100,000 |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 289,100,000 |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | DM1 License [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 76,200,000 |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 51,300,000 |  |  | 51,300,000 |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  | 12,000,000.0 |  | 202,400,000 |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Specified Target Option Material Right [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 17,500,000 |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 11,800,000 |  |  | 11,800,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Collaboration Target Options Material Rights One [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Collaboration Target Options Material Rights Two [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 22,200,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Collaboration Target Options Material Rights Three [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 22,200,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Collaborative Arrangement Material Rights Fourth Exclusive License [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 10,000,000.0 |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 6,700,000 |  |  | 6,700,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Exclusive License [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  | 900,000,000.0 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Waiving of Vertex Material Right [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | 6,700,000 |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Research and Development Services [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | 2015 Collaboration Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment receivable |  |  |  |  | 395,000,000.0 |  |  | $ 395,000,000.0 |  |  |  |  |  |  |  |
Percentage of exchange payment of research and development costs |  |  |  |  |  |  |  | 50.00% |  |  |  |  |  |  |  |
Number of options would not be exercised under agreement | Option |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |
Number of remaining options under agreement | Option |  |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |
Non-current deferred revenue |  |  |  |  | 57,800,000 |  |  | $ 57,800,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | 2019 Collaboration Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Nonrefundable upfront payment received |  |  |  |  |  |  |  | 175,000,000.0 |  |  |  |  |  |  |  |
Variable consideration adjusted to transaction price |  |  |  |  | 12,500,000 |  |  |  |  |  |  |  |  |  |  |
Revenue recognized |  |  |  |  | 12,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Maximum potential payments |  |  |  |  | 825,000,000 |  |  | $ 825,000,000 |  |  |  |  |  |  |  |
Percentage of exchange payment of research and development costs |  |  |  |  |  |  |  | 50.00% |  |  |  |  |  |  |  |
Transaction price allocated to remaining performance obligations |  |  |  |  | 500,000 |  |  | $ 500,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Joint Development Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Up-front payment received |  |  |  |  |  |  |  | $ 7,000,000.0 |  |  |  |  |  |  |  |
Agreement description |  |  |  |  |  |  |  | In connection with the JDA, the Company received a $7.0 million up-front payment from Vertex and subsequently received a one-time low seven-digit milestone payment upon the dosing of the second patient in a clinical trial with the initial product candidate. |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member] | Exercise of Exclusive Option [Member] | Collaboration Target Options [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment receivable |  |  |  |  | 10,000,000 |  |  | $ 10,000,000 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Inc [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum potential future payments |  |  |  |  |  |  |  | 200,000,000.0 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Inc [Member] | Exclusive License [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated standalone selling price for single collaboration |  |  |  |  |  |  |  | 900,000,000.0 |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Inc [Member] | A&R Vertex JDCA [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Up-front payment received |  | $ 900,000,000.0 |  |  |  |  |  | $ 900,000,000.0 |  |  |  |  |  |  |  |
Milestone payment receivable |  | $ 200,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of net profits and net losses |  |  |  |  |  |  |  |  |  |  | 60.00% | 60.00% |  |  |  |
Additional interest of percentage |  |  |  |  |  |  |  | 10.00% |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Inc [Member] | 2015 Collaboration Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate amount in option exercise payments received |  |  |  |  |  |  | $ 30,000,000.0 |  |  |  |  |  |  |  |  |
Number of exclusive license targets | License |  |  |  |  |  | 3 |  |  |  |  |  |  |  |  |  |
Vertex Pharmaceuticals Inc [Member] | 2019 Collaboration Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment receivable |  |  |  |  | 12,500,000 |  |  | $ 12,500,000 |  |  |  |  | $ 25,000,000.0 |  |  |
Remaining milestone payment receivable |  |  |  |  | $ 775,000,000.0 |  |  | $ 775,000,000.0 |  |  |  |  |  |  |  |
[1] | Including the following amounts of research and development from a related party, see Note 9

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