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Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Contingencies And Commitments [Line Items] |  |  |
Cost sharing expensed relating to patent maintenance, defense and prosecution, incurred | $ 5.8 | $ 4.5 | $ 2.9
Cost sharing expensed relating to patent maintenance, defense and prosecution, accrued | 4.0 | $ 2.5 |
2015 Collaboration Agreement [Member] | Vertex [Member] |  |  |
Contingencies And Commitments [Line Items] |  |  |
Milestone payment receivable | $ 395.0 |  |

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- Definition Contingencies and commitments. + References No definition available. + Details
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- Details
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