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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Valuation Allowance [Line Items] |  |  |  |
Decrease in valuation allowance | $ 18,000,000.0 |  |  |
U.S. federal net operating loss carryforwards | 3,300,000 |  |  |
Non-US Net operating loss carryforwards | $ 772,900,000 |  |  |
Operating loss carryforwards expiration period | 2027 |  |  |
Unrecognized tax benefits, gross | $ 21,395,000 | $ 11,967,000 | $ 5,231,000 | $ 1,595,000
Unrecognized tax benefits would favorably impact the effective tax rate if recognized | 19,900,000 |  |  |
Accrued interest or penalties related to uncertain tax positions | 0 | 0 | 0 |
Uncertain tax positions recognized | 0 | $ 0 | $ 0 |
U.S. Domestic Federal [Member] | Research and Development [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Tax credit carryforward amount | $ 19,400,000 |  |  |
Tax credit carryforward, expiration year | 2039 |  |  |
Uncertain tax positions | $ 9,900,000 |  |  |
U.S. Domestic Federal [Member] | Orphan Drug Credit Carryforwards [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Tax credit carryforward amount | $ 10,600,000 |  |  |
Tax credit carryforward, expiration year | 2040 |  |  |
Uncertain tax positions | $ 4,500,000 |  |  |
U.S. Domestic State [Member] | Research and Development [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Tax credit carryforward amount | $ 10,000,000.0 |  |  |
Tax credit carryforward, expiration year | 2035 |  |  |
Uncertain tax positions | $ 7,000,000.0 |  |  |
Switzerland [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Non-US Net operating loss carryforwards | 385,200,000 |  |  |
Canton of Zug [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Non-US Net operating loss carryforwards | 385,200,000 |  |  |
United Kingdom [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Non-US Net operating loss carryforwards | $ 2,500,000 |  |  |

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