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Summary of Significant Accounting Policies and Basis of Presentation - Additional Information (Detail) | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2021 USD ($) Segment | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 12, 2019 | Mar. 31, 2016 | Feb. 12, 2016
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Number of operating segments | Segment | 1 |  |  |  |  |
Cash and cash equivalents | $ 923,031,000 | $ 1,168,620,000 | $ 943,771,000 |  |  |
Restricted Cash | 16,913,000 | 16,848,000 | 5,041,000 |  |  |
Marketable securities | 1,456,098,000 | 521,713,000 |  |  |  |
Contract liabilities | 12,300,000 | 12,200,000 |  |  |  |
Net lease assets | 174,460,000 | 50,865,000 |  |  |  |
Net lease liabilities | 225,030,000 | 61,429,000 |  |  |  |
Significant uncertain tax positions | $ 0 | 0 | $ 0 |  |  |
Minimum [Member] |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Marketable securities maturity period | 1 year |  |  |  |  |
Vertex and Casebia [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Other receivables | $ 8,400 | $ 10,700,000 |  |  |  |
ASC 326 [Member] |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Change in accounting principle, accounting standards update, adopted | true |  |  |  |  |
Change in accounting principle, accounting standards update, adoption date | Jan. 01, 2020 |  |  |  |  |
Change in accounting principle, accounting standards update, immaterial effect | true |  |  |  |  |
ASU 2019-12 [Member] |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Change in accounting principle, accounting standards update, adopted | true |  |  |  |  |
Change in accounting principle, accounting standards update, adoption date | Jan. 01, 2021 |  |  |  |  |
Change in accounting principle, accounting standards update, immaterial effect | true |  |  |  |  |
Casebia Therapeutics Llp [Member] |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Equity method investment, ownership percentage | 50.00% |  |  | 50.00% | 50.00% | 50.00%

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- Definition Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3044-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=124098289&loc=d3e6676-107765 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.1) -URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 + Details
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