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Commitments and Contingencies - Additional Information (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Contingencies And Commitments [Line Items]      
Cost sharing expensed relating to patent maintenance, defense and prosecution, incurred $ 5.8 $ 4.5 $ 2.9
Cost sharing expensed relating to patent maintenance, defense and prosecution, accrued 4.0 $ 2.5  
2015 Collaboration Agreement [Member] | Vertex [Member]      
Contingencies And Commitments [Line Items]      
Milestone payment receivable $ 395.0