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Income Taxes - Additional Information (Detail) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Valuation Allowance [Line Items]        
Decrease in valuation allowance $ 18,000,000.0      
U.S. federal net operating loss carryforwards 3,300,000      
Non-US Net operating loss carryforwards $ 772,900,000      
Operating loss carryforwards expiration period 2027      
Unrecognized tax benefits, gross $ 21,395,000 $ 11,967,000 $ 5,231,000 $ 1,595,000
Unrecognized tax benefits would favorably impact the effective tax rate if recognized 19,900,000      
Accrued interest or penalties related to uncertain tax positions 0 0 0  
Uncertain tax positions recognized 0 $ 0 $ 0  
U.S. Domestic Federal [Member] | Research and Development [Member]        
Valuation Allowance [Line Items]        
Tax credit carryforward amount $ 19,400,000      
Tax credit carryforward, expiration year 2039      
Uncertain tax positions $ 9,900,000      
U.S. Domestic Federal [Member] | Orphan Drug Credit Carryforwards [Member]        
Valuation Allowance [Line Items]        
Tax credit carryforward amount $ 10,600,000      
Tax credit carryforward, expiration year 2040      
Uncertain tax positions $ 4,500,000      
U.S. Domestic State [Member] | Research and Development [Member]        
Valuation Allowance [Line Items]        
Tax credit carryforward amount $ 10,000,000.0      
Tax credit carryforward, expiration year 2035      
Uncertain tax positions $ 7,000,000.0      
Switzerland [Member]        
Valuation Allowance [Line Items]        
Non-US Net operating loss carryforwards 385,200,000      
Canton of Zug [Member]        
Valuation Allowance [Line Items]        
Non-US Net operating loss carryforwards 385,200,000      
United Kingdom [Member]        
Valuation Allowance [Line Items]        
Non-US Net operating loss carryforwards $ 2,500,000