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Summary of Significant Accounting Policies and Basis of Presentation - Additional Information (Detail) | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2024 USD ($) Segment | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($)
Summary Of Significant Accounting Policies [Line Items] |  |  |
Number of operating segments | Segment | 1 |  |
Cash and cash equivalents | $ 298,257,000 | $ 389,477,000 | $ 211,885,000
Letters of credit secured by cash held in restricted depository account | 0 | 0 | 540,000
Marketable securities | 193,900,000 | 197,800,000 |
Accounts receivable | 25,000,000 | 200,000,000 |
Contract liabilities | 12,300,000 | 12,300,000 |
Significant uncertain tax positions | $ 0 | 0 | $ 0
Minimum [Member] |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |
Marketable securities maturity period | 1 year |  |
Vertex and Casebia [Member] | Hemoglobinopathy Agreements [Member] |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |
Other receivables | $ 2,100,000 | 6,500,000 |
Marketable Securities [Member] |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |
Marketable securities | 1,605,600,000 | 1,306,200,000 |
Letter of Credit [Member] |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |
Letters of credit secured by cash held in restricted depository account | $ 11,500,000 | $ 11,600,000 |

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