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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Valuation Allowance [Line Items] |  |  |  |
Increase in valuation allowance | $ 55,100,000 |  |  |
U.S. federal net operating loss carryforwards | 0 |  |  |
Non-US Net operating loss carryforwards | $ 2,982,000,000 |  |  |
Operating loss carryforwards expiration period | 2027 |  |  |
Unrecognized tax benefits, gross | $ 49,959,000 | $ 44,148,000 | $ 34,536,000 | $ 21,395,000
Unrecognized tax benefits would favorably impact the effective tax rate if recognized | 45,600,000 |  |  |
Accrued interest or penalties related to uncertain tax positions |  | 0 | 0 |
Uncertain tax positions recognized | 0 | $ 0 | $ 0 |
U.S. Domestic Federal [Member] | Research and Development [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Tax credit carryforward amount | $ 29,800,000 |  |  |
Tax credit carryforward, expiration year | 2040 |  |  |
Uncertain tax positions | $ 22,300,000 |  |  |
U.S. Domestic Federal [Member] | Orphan Drug Credit Carryforwards [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Tax credit carryforward amount | $ 27,000,000 |  |  |
Tax credit carryforward, expiration year | 2040 |  |  |
Uncertain tax positions | $ 11,500,000 |  |  |
U.S. Domestic State [Member] | Research and Development [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Tax credit carryforward amount | $ 21,800,000 |  |  |
Tax credit carryforward, expiration year | 2035 |  |  |
Uncertain tax positions | $ 14,500,000 |  |  |
Switzerland [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Non-US Net operating loss carryforwards | 1,489,700,000 |  |  |
Canton of Zug [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Non-US Net operating loss carryforwards | 1,489,700,000 |  |  |
United Kingdom [Member] |  |  |  |
Valuation Allowance [Line Items] |  |  |  |
Non-US Net operating loss carryforwards | $ 2,600,000 |  |  |

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