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v3.25.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Operating activities |  |  |
Net loss | $ (366,252) | $ (153,610) | $ (650,175)
Reconciliation of net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 19,259 | 19,837 | 24,172
Stock-based compensation | 86,567 | 81,028 | 97,947
Other non-cash items, net | (38,618) | (16,545) | 12,470
Acquired in-process research and development | 0 | 2,500 | 0
Changes in: |  |  |
Accounts receivable | 175,000 | (200,000) | 305
Prepaid expenses and other assets | 5,285 | 23,219 | 1,598
Accounts payable and accrued expenses | (27,283) | (20,247) | 5,164
Deferred revenue | (1,949) | 5,794 | (1,011)
Operating lease assets and liabilities | (4,407) | (2,461) | 15,310
Other liabilities, net | 9,624 | 110 | (1,521)
Net cash used in operating activities | (142,774) | (260,375) | (495,741)
Investing activities |  |  |
Purchase of property, plant and equipment | (1,901) | (9,470) | (37,188)
Purchase of in-process research and development | 0 | (2,500) | 0
Investment in equity securities | (23,183) | 0 | 0
Purchases of marketable debt securities | (1,463,196) | (1,065,911) | (1,417,800)
Maturities of marketable debt securities | 1,207,799 | 1,452,528 | 1,196,333
Net cash (used in) provided by investing activities | (280,481) | 374,647 | (258,655)
Financing activities |  |  |
Proceeds from issuance of common shares, net of issuance costs | 300,695 | 32,721 | 970
Proceeds from exercise of options and ESPP contributions, net of issuance costs | 31,289 | 29,943 | 37,622
Net cash provided by financing activities | 331,984 | 62,664 | 38,592
Effect of exchange rate changes on cash | (21) | 73 | (80)
(Decrease) increase in cash | (91,292) | 177,009 | (715,884)
Cash, cash equivalents and restricted cash, beginning of period | 401,068 | 224,060 | 939,944
Cash, cash equivalents and restricted cash, end of period | 309,776 | 401,068 | 224,060
Supplemental disclosure of non-cash investing and financing activities |  |  |
Property and equipment purchases in accounts payable and accrued expenses | 154 | 725 | 2,121
Equity issuance costs in accounts payable and accrued expenses | $ 3,371 | $ 417 | $ 99

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