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Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands | Total | Common Shares [Member] | Treasury Shares [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Accumulated Other Comprehensive (Loss) Income [Member]
--- | --- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2021 | $ 2,399,460 | $ 2,391 | $ (63) | $ 2,598,114 | $ (195,915) | $ (5,067)
Beginning balance (in shares) at Dec. 31, 2021 |  | 76,990,066 | 180,316 |  |  |
Issuance of common shares, net of issuance costs | 970 |  |  | 970 |  |
Issuance of common shares, net of issuance costs (in shares) |  | 12,365 |  |  |  |
Vesting of restricted shares | 8 | $ 8 |  |  |  |
Vesting of restricted shares (in shares) |  | 237,932 |  |  |  |
Exercise of vested options, net of issuance costs | 35,813 | $ 42 |  | 35,771 |  |
Exercise of vested options, net of issuance costs (in shares) |  | 1,235,528 |  |  |  |
Purchase of common stock under ESPP | 2,036 |  |  | 2,036 |  |
Purchase of common stock under ESPP (in shares) |  | 36,559 |  |  |  |
Stock-based compensation expense | 97,947 |  |  | 97,947 |  |
Other comprehensive loss | (10,580) |  |  |  |  | (10,580)
Net loss | (650,175) |  |  |  | (650,175) |
Ending balance at Dec. 31, 2022 | 1,875,479 | $ 2,441 | $ (63) | 2,734,838 | (846,090) | (15,647)
Ending balance (in shares) at Dec. 31, 2022 |  | 78,512,450 | 180,316 |  |  |
Issuance of common shares, net of issuance costs | 32,394 | $ 15 |  | 32,379 |  |
Issuance of common shares, net of issuance costs (in shares) |  | 458,547 |  |  |  |
Vesting of restricted shares | 10 | $ 10 |  |  |  |
Vesting of restricted shares (in shares) |  | 277,808 |  |  |  |
Exercise of vested options, net of issuance costs | 28,103 | $ 31 | $ 1 | 28,071 |  |
Exercise of vested options, net of issuance costs (in shares) |  | 742,291 | (10,000) |  |  |
Purchase of common stock under ESPP | 1,839 |  |  | 1,839 |  |
Purchase of common stock under ESPP (in shares) |  | 53,282 |  |  |  |
Stock-based compensation expense | 81,028 |  |  | 81,028 |  |
Other comprehensive loss | 17,560 |  |  |  |  | 17,560
Net loss | (153,610) |  |  |  | (153,610) |
Ending balance at Dec. 31, 2023 | 1,882,803 | $ 2,497 | $ (62) | 2,878,155 | (999,700) | 1,913
Ending balance (in shares) at Dec. 31, 2023 |  | 80,044,378 | 170,316 |  |  |
Issuance of common shares, net of issuance costs | 297,702 | $ 145 |  | 297,557 |  |
Issuance of common shares, net of issuance costs (in shares) |  | 4,309,521 |  |  |  |
Vesting of restricted shares | 16 | $ 16 |  |  |  |
Vesting of restricted shares (in shares) |  | 450,701 |  |  |  |
Exercise of vested options, net of issuance costs | $ 29,579 | $ 40 |  | 29,539 |  |
Exercise of vested options, net of issuance costs (in shares) | 900,136 | 900,136 |  |  |  |
Purchase of common stock under ESPP | $ 1,738 |  |  | 1,738 |  |
Purchase of common stock under ESPP (in shares) |  | 37,245 |  |  |  |
Stock-based compensation expense | 86,567 |  |  | 86,567 |  |
Other comprehensive loss | (73) |  |  |  |  | (73)
Net loss | (366,252) |  |  |  | (366,252) |
Ending balance at Dec. 31, 2024 | $ 1,932,080 | $ 2,698 | $ (62) | $ 3,293,556 | $ (1,365,952) | $ 1,840
Ending balance (in shares) at Dec. 31, 2024 |  | 85,741,981 | 170,316 |  |  |

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