    <SEC-DOCUMENT>0001193125-26-165183-index.html : 20260421
    <SEC-HEADER>0001193125-26-165183.hdr.sgml : 20260421
    <ACCEPTANCE-DATETIME>20260421081811
    ACCESSION NUMBER:		0001193125-26-165183
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260421
    DATE AS OF CHANGE:		20260421
    EFFECTIVENESS DATE:		20260421

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			CRISPR Therapeutics AG
    		CENTRAL INDEX KEY:			0001674416
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				473173478
    		STATE OF INCORPORATION:			V8
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-37923
    		FILM NUMBER:		26876801

    	BUSINESS ADDRESS:
    		ADDRESS IS A NON US LOCATION: 	YES
    		STREET 1:		BAARERSTRASSE 14
    		CITY:			ZUG
    		PROVINCE COUNTRY:   	V8
    		BUSINESS PHONE:		6173154600

    	MAIL ADDRESS:
    		ADDRESS IS A NON US LOCATION: 	YES
    		STREET 1:		BAARERSTRASSE 14
    		CITY:			ZUG
    		PROVINCE COUNTRY:   	V8
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>2025_ars_for_2026_proxy.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: 2025_ars_for_2026_proxy.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>