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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2021-11-04T16:42:50.2843347+00:00 -->
<!-- Version            : 5.0.1.702 -->
<!-- Package ID         : 2f94bf296a7e4916bf51ad8d0e9701d6 -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="hwc_PayrollTaxesHealthcareCostsPensionAndOtherPostretirementBenefitExpense" name="PayrollTaxesHealthcareCostsPensionAndOtherPostretirementBenefitExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_DepositInsuranceAndRegulatoryFees" name="DepositInsuranceAndRegulatoryFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_OtherRealEstateAndForeclosedRealEstateIncomeExpense" name="OtherRealEstateAndForeclosedRealEstateIncomeExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossUnrealizedHoldingGainLossOnSecuritiesAndDerivativesArisingDuringPeriodBeforeTax" name="OtherComprehensiveIncomeLossUnrealizedHoldingGainLossOnSecuritiesAndDerivativesArisingDuringPeriodBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociPensionPlanAttributableToTheVoluntaryEarlyRetirementProgramAndCurtailment" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociPensionPlanAttributableToTheVoluntaryEarlyRetirementProgramAndCurtailment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossAmortizationOnUnrealizedHoldingGainLossOnTransfersToHeldToMaturitySecuritiesBeforeTax" name="OtherComprehensiveIncomeLossAmortizationOnUnrealizedHoldingGainLossOnTransfersToHeldToMaturitySecuritiesBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_StockIssuedDuringPeriodValueShareBasedCompensationDividendsPreviousPaidOnSharesForfeited" name="StockIssuedDuringPeriodValueShareBasedCompensationDividendsPreviousPaidOnSharesForfeited" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_AcceleratedShareRepurchaseProgramAdjustmentShares" name="AcceleratedShareRepurchaseProgramAdjustmentShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_GainLossOnOtherRealEstateAndForeclosedAssets" name="GainLossOnOtherRealEstateAndForeclosedAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_NetChangeInLiabilityFromVariationMarginCollateral" name="NetChangeInLiabilityFromVariationMarginCollateral" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_SettlementOfForwardContractPortionOfAcceleratedShareRepurchase" name="SettlementOfForwardContractPortionOfAcceleratedShareRepurchase" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_NonInterestIncomeDisclosureTextBlock" name="NonInterestIncomeDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_OtherNonInterestExpenseDisclosureTextBlock" name="OtherNonInterestExpenseDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_ResidentialPortfolioSegmentAndConsumerPortfolioSegmentMember" name="ResidentialPortfolioSegmentAndConsumerPortfolioSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_ScheduleOfLongTermDebtInstrumentsWithRelatedUnamortizedDebtIssuanceCostTableTextBlock" name="ScheduleOfLongTermDebtInstrumentsWithRelatedUnamortizedDebtIssuanceCostTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_OffsettingDerivativeAssetsAndLiabilitiesTableTextBlock" name="OffsettingDerivativeAssetsAndLiabilitiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_ScheduleOfComponentOfOtherNonoperatingIncomeTableTextBlock" name="ScheduleOfComponentOfOtherNonoperatingIncomeTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_AvailableForSaleSecuritiesAmortizedCostExcludingAccruedInterest" name="AvailableForSaleSecuritiesAmortizedCostExcludingAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_SalesOfSecurities" name="SalesOfSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_NumberOfSecuritiesMetCriteriaOfCreditLossEvent" name="NumberOfSecuritiesMetCriteriaOfCreditLossEvent" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_NumberOfSecuritiesWithMarketValuesBelowCostBasis" name="NumberOfSecuritiesWithMarketValuesBelowCostBasis" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_LoansAndLeasesAccruedInterest" name="LoansAndLeasesAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_LoansAndLeasesPaycheckProtectionProgramLoans" name="LoansAndLeasesPaycheckProtectionProgramLoans" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_CommercialNonRealEstateMember" name="CommercialNonRealEstateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_DownsideScenariosSTwoMember" name="DownsideScenariosSTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_TroubledDebtRestructuringsMember" name="TroubledDebtRestructuringsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_LoanOneMember" name="LoanOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_LoanFourMember" name="LoanFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_LoanThreeMember" name="LoanThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_CommercialRealEstateOwnerOccupiedMember" name="CommercialRealEstateOwnerOccupiedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_CommercialRealEstateIncomeProducingMember" name="CommercialRealEstateIncomeProducingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_LoansReceivableInterestBearingRate" name="LoansReceivableInterestBearingRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_LoansReceivableTerm" name="LoansReceivableTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_LoansReceivablePercentageOfOriginationFee" name="LoansReceivablePercentageOfOriginationFee" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_LoansReceivablePercentageOfOriginationFeeDescription" name="LoansReceivablePercentageOfOriginationFeeDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_ProvisionForLossesOnUnfundedCreditCommitments" name="ProvisionForLossesOnUnfundedCreditCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_FinancingReceivableCumulativeEffectOfChangeInAccountingPrinciple" name="FinancingReceivableCumulativeEffectOfChangeInAccountingPrinciple" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_ReserveForUnfundedLendingCommitments" name="ReserveForUnfundedLendingCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_ReserveForUnfundedLendingCommitmentsIndividuallyEvaluatedForImpairment" name="ReserveForUnfundedLendingCommitmentsIndividuallyEvaluatedForImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_ReserveForUnfundedLendingCommitmentsCollectivelyEvaluatedForImpairment" name="ReserveForUnfundedLendingCommitmentsCollectivelyEvaluatedForImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_NonPurchasedCreditImpairedMember" name="NonPurchasedCreditImpairedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_WeightedAveragePercentageOfForecast" name="WeightedAveragePercentageOfForecast" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_BuildBackBetterInfrastructureAndSocialLegislationPackageForecastedAmount" name="BuildBackBetterInfrastructureAndSocialLegislationPackageForecastedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_UnemploymentPercentageRateForecast" name="UnemploymentPercentageRateForecast" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_GrossDomesticProductWeightedAverage" name="GrossDomesticProductWeightedAverage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_FederalReserveRate" name="FederalReserveRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_FinancingReceivableModificationsExtendedTermsAndOtherPaymentConcessions" name="FinancingReceivableModificationsExtendedTermsAndOtherPaymentConcessions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_FinancingReceivableModificationsReductionOfInterestRate" name="FinancingReceivableModificationsReductionOfInterestRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_FinancingReceivableModificationsPaymentSignificantCovenantWaiversAndOtherModifications" name="FinancingReceivableModificationsPaymentSignificantCovenantWaiversAndOtherModifications" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_FinancingReceivableModificationsCovenantWaivers" name="FinancingReceivableModificationsCovenantWaivers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_PassWatchMember" name="PassWatchMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_FinancingReceivableRevolvingLoansConvertedToTermLoans" name="FinancingReceivableRevolvingLoansConvertedToTermLoans" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_OtherLongTermDebtMember" name="OtherLongTermDebtMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_SubordinatedNotesPayableMaturingOnJuneTwoThousandAndFortyFiveMember" name="SubordinatedNotesPayableMaturingOnJuneTwoThousandAndFortyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_SubordinatedNotesPayableMaturingOnJuneTwoThousandSixtyMember" name="SubordinatedNotesPayableMaturingOnJuneTwoThousandSixtyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_DebtInstrumentRedemptionPricePercentageOfPrincipalPlusAccruedAndUnpaidInterest" name="DebtInstrumentRedemptionPricePercentageOfPrincipalPlusAccruedAndUnpaidInterest" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_SubordinatedNotesPayableMaturingOnJuneTwoThousandFortyFiveMember" name="SubordinatedNotesPayableMaturingOnJuneTwoThousandFortyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_OtherLongTermDebtMaturityDateRangeEnd" name="OtherLongTermDebtMaturityDateRangeEnd" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_InterestRateSwapsVariableRateLoansMember" name="InterestRateSwapsVariableRateLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_InterestRateSwapsSecuritiesMember" name="InterestRateSwapsSecuritiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_ToBeAnnouncedSecuritiesMember" name="ToBeAnnouncedSecuritiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_VisaClassBDerivativeContractMember" name="VisaClassBDerivativeContractMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_DerivativeAssetsBeforeNettingAdjustments" name="DerivativeAssetsBeforeNettingAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_DerivativeMaturityYear" name="DerivativeMaturityYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_AgreementOneMember" name="AgreementOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_AgreementTwoMember" name="AgreementTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_AgreementThreeMember" name="AgreementThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_AgreementFourMember" name="AgreementFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_AgreementFiveMember" name="AgreementFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_SecuritiesTransactionsNetMember" name="SecuritiesTransactionsNetMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_SecondaryMortgageMarketOperationsMember" name="SecondaryMortgageMarketOperationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_OtherNoninterestIncomeMember" name="OtherNoninterestIncomeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_InterestRateSwapsSecuritiesTerminationMember" name="InterestRateSwapsSecuritiesTerminationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_InterestRateSwapsBrokeredDepositsMember" name="InterestRateSwapsBrokeredDepositsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_DerivativeFairValueOfDerivativeAssetsLiabilityAmountOffsetAgainstCollateral" name="DerivativeFairValueOfDerivativeAssetsLiabilityAmountOffsetAgainstCollateral" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_TwoThousandEighteenStockRepurchasePlanMember" name="TwoThousandEighteenStockRepurchasePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_AcceleratedShareRepurchaseAgreementMember" name="AcceleratedShareRepurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_RegulatoryCapitalTransitionForFirstTwoYearsMember" name="RegulatoryCapitalTransitionForFirstTwoYearsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyTwoMember" name="RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyThreeMember" name="RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyFourMember" name="RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyFourAndThereafterMember" name="RegulatoryCapitalThreeYearTransitionYearTwoThousandTwentyFourAndThereafterMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_PercentageOfSharesRepurchasedAmongAuthorized" name="PercentageOfSharesRepurchasedAmongAuthorized" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_ValuationAdjustmentsToPensionPlanAttributableToVERIPAndCurtailment" name="ValuationAdjustmentsToPensionPlanAttributableToVERIPAndCurtailment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossOtherValuationAdjustmentsToEmployeeBenefitPlans" name="OtherComprehensiveIncomeLossOtherValuationAdjustmentsToEmployeeBenefitPlans" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIVoluntaryEarlyRetirementIncentiveProgram" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIVoluntaryEarlyRetirementIncentiveProgram" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_HeldToMaturitySecuritiesTransferredFromAvailableForSaleMember" name="HeldToMaturitySecuritiesTransferredFromAvailableForSaleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnAvailableForSaleSecuritiesToHeldToMaturityBeforeTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnAvailableForSaleSecuritiesToHeldToMaturityBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnAvailableForSaleSecuritiesToHeldToMaturityTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnAvailableForSaleSecuritiesToHeldToMaturityTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnAvailableForSaleSecuritiesToHeldToMaturityNetOfTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnAvailableForSaleSecuritiesToHeldToMaturityNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnReclassificationBeforeTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnReclassificationBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnUnrealizedGainOnCashFlowHedgesTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnUnrealizedGainOnCashFlowHedgesTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnUnrealizedGainOnCashFlowHedgesNetOfTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnUnrealizedGainOnCashFlowHedgesNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnEquityMethodInvestmentBeforeTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnEquityMethodInvestmentBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnEquityMethodInvestmentTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnEquityMethodInvestmentTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnEquityMethodInvestmentNetOfTax" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociForTransfersFromUnrealizedNetGainLossesOnEquityMethodInvestmentNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociNetOfTaxTotal" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAociNetOfTaxTotal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_EquityMethodInvestmentsTransferredFromAvailableForSaleMember" name="EquityMethodInvestmentsTransferredFromAvailableForSaleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_RegulatoryCapitalTransitionPercentage" name="RegulatoryCapitalTransitionPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_RegulatoryCapitalModifiedTransitionAmountPercentage" name="RegulatoryCapitalModifiedTransitionAmountPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_LetterOfCreditFees" name="LetterOfCreditFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_GainLossOnSaleOfStock" name="GainLossOnSaleOfStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_GainOnSaleOfFunds" name="GainOnSaleOfFunds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_OtherMiscellaneousNoninterestIncome" name="OtherMiscellaneousNoninterestIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_AdValoremAndFranchiseTaxes" name="AdValoremAndFranchiseTaxes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_EntertainmentAndContributions" name="EntertainmentAndContributions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_TaxCreditInvestmentAmortization" name="TaxCreditInvestmentAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_TravelExpense" name="TravelExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_NetOtherRetirementExpenseIncome" name="NetOtherRetirementExpenseIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_LossOnFacilitiesAndEquipmentFromConsolidation" name="LossOnFacilitiesAndEquipmentFromConsolidation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_OtherMiscellaneousNoninterestExpense" name="OtherMiscellaneousNoninterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_UndistributedEarningAllocatedToParticipatingSecurities" name="UndistributedEarningAllocatedToParticipatingSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="hwc_NetIncomeLossAllocatedToCommonShareholdersBasicAndDiluted" name="NetIncomeLossAllocatedToCommonShareholdersBasicAndDiluted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="hwc_DefinedContributionPlanInitialSavingsRate" name="DefinedContributionPlanInitialSavingsRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_DefinedContributionPlanEmployerMatchingContributionAdditionalPercentOfMatch" name="DefinedContributionPlanEmployerMatchingContributionAdditionalPercentOfMatch" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_DefinedContributionPlanPeriodOfEmploymentForEligibility" name="DefinedContributionPlanPeriodOfEmploymentForEligibility" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_AmendedHancock401kPlanMember" name="AmendedHancock401kPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_FirstOnePercentOfContributionSavedMember" name="FirstOnePercentOfContributionSavedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_NextFivePercentOfContributionSavedMember" name="NextFivePercentOfContributionSavedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_FourPercentOfContributionMember" name="FourPercentOfContributionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_SixPercentOfContributionMember" name="SixPercentOfContributionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_TwoPercentOfContributionMember" name="TwoPercentOfContributionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_DefinedBenefitPensionPlanEligibleParticipantsUnderVoluntaryEarlyRetirementIncentiveProgram" name="DefinedBenefitPensionPlanEligibleParticipantsUnderVoluntaryEarlyRetirementIncentiveProgram" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_RestrictedAndPerformanceSharesMember" name="RestrictedAndPerformanceSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_TotalShareholderReturnMember" name="TotalShareholderReturnMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_OperatingEarningsPerShareMember" name="OperatingEarningsPerShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_NumberOfPeerGroupRegionalBanks" name="NumberOfPeerGroupRegionalBanks" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_VisaIncMember" name="VisaIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_NumberOfSharesWithDerivativeContract" name="NumberOfSharesWithDerivativeContract" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="hwc_MeasurementInputVisaClassAppreciationMember" name="MeasurementInputVisaClassAppreciationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="hwc_RecentAccountingPronouncementsLineItems" name="RecentAccountingPronouncementsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="hwc_RecentAccountingPronouncementsTable" name="RecentAccountingPronouncementsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
