<SEC-DOCUMENT>0001971857-23-000009.txt : 20230419
<SEC-HEADER>0001971857-23-000009.hdr.sgml : 20230419
<ACCEPTANCE-DATETIME>20230419161927
ACCESSION NUMBER:		0001971857-23-000009
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230419
DATE AS OF CHANGE:		20230419

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Krystal Biotech, Inc.
		CENTRAL INDEX KEY:			0001711279
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				821080209
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38210
		FILM NUMBER:		23830259

	BUSINESS ADDRESS:	
		STREET 1:		2100 WHARTON STREET
		STREET 2:		SUITE 701
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203
		BUSINESS PHONE:		(412) 586-5830

	MAIL ADDRESS:	
		STREET 1:		2100 WHARTON STREET
		STREET 2:		SUITE 701
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			JANNEY DANIEL
		CENTRAL INDEX KEY:			0001198325

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		PO BOX 7414
		CITY:			JACKSON
		STATE:			WY
		ZIP:			83002
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <submissionType>144</submissionType>
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      <filer>
        <filerCredentials>
          <cik>0001198325</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001711279</issuerCik>
      <issuerName>Krystal Biotech, Inc.</issuerName>
      <secFileNumber>001-38210</secFileNumber>
      <issuerAddress>
        <com:street1>2100 WHARTON STREET</com:street1>
        <com:street2>SUITE 701</com:street2>
        <com:city>PITTSBURGH</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>15203</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(412) 586-5830</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JANNEY DANIEL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>KRYSTAL BIOTECH, INC.</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>MERRILL LYNCH</name>
        <address>
          <com:street1>555 CALIFORNIA ST, SUITE 1800</com:street1>
          <com:city>SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>25000</noOfUnitsSold>
      <aggregateMarketValue>2250000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>25747647</noOfUnitsOutstanding>
      <approxSaleDate>04/19/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>08/25/2017</acquiredDate>
      <natureOfAcquisitionTransaction>PRIVATE PURCHASE</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>KRYSTAL BIOTECH, INC</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>25000</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2017</paymentDate>
      <natureOfPayment>CASH</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>DAN JANNEY IS SELLING ON BEHALF OF ALTA BIOEQUITIES, LP.  HE IS THE OWNER OF THIS LP.</remarks>
    <noticeSignature>
      <noticeDate>04/19/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/10/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>DANIEL S. JANNEY, MANAGER</signature>
    </noticeSignature>
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