<SEC-DOCUMENT>0001298711-26-000002.txt : 20260303
<SEC-HEADER>0001298711-26-000002.hdr.sgml : 20260303
<ACCEPTANCE-DATETIME>20260303183307
ACCESSION NUMBER:		0001298711-26-000002
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20260227
FILED AS OF DATE:		20260303
DATE AS OF CHANGE:		20260303

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Krishnan Suma
		CENTRAL INDEX KEY:			0001298711
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38210
		FILM NUMBER:		26717509

	MAIL ADDRESS:	
		STREET 1:		2100 WHARTON STREET
		STREET 2:		SUITE 701
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Krystal Biotech, Inc.
		CENTRAL INDEX KEY:			0001711279
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				821080209
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2100 WHARTON STREET
		STREET 2:		SUITE 701
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203
		BUSINESS PHONE:		(412) 586-5830

	MAIL ADDRESS:	
		STREET 1:		2100 WHARTON STREET
		STREET 2:		SUITE 701
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
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    <footnotes>
        <footnote id="F1">45,000 performance stock units (&quot;PSUs&quot;) were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 22,500 PSUs, vested on February 27, 2026.</footnote>
        <footnote id="F2">Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 22,500 PSUs on February 27, 2026.</footnote>
        <footnote id="F3">The closing price on February 27, 2026 of the Company's common stock on the Nasdaq Global Select Market.</footnote>
        <footnote id="F4">16,000 restricted stock units (&quot;RSUs&quot;) were granted on February 28, 2025. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 4,000 RSUs, vesting on February 27, 2026.</footnote>
        <footnote id="F5">Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 4,000 RSUs on February 27, 2026.</footnote>
        <footnote id="F6">35,000 restricted stock units (&quot;RSUs&quot;) were granted on February 29, 2024, to the Reporting Person's spouse, Krish S. Krishnan. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the second installment, or 8,750 RSUs, vesting on February 27, 2026.</footnote>
        <footnote id="F7">These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.</footnote>
        <footnote id="F8">Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.</footnote>
        <footnote id="F9">Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 8,750 RSUs on February 27, 2026.</footnote>
        <footnote id="F10">52,500 PSUs were granted on February 29, 2024, to the Reporting Person's spouse, Krish S. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 26,250 PSUs, vested on February 27, 2026.</footnote>
        <footnote id="F11">Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 26,250 PSUs on February 27, 2026.</footnote>
        <footnote id="F12">22,900 restricted stock units (&quot;RSUs&quot;) were granted on February 28, 2025, to the Reporting Person's spouse, Krish S. Krishnan. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 5,725 RSUs, vesting on February 27, 2026.</footnote>
        <footnote id="F13">Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 5,725 RSUs on February 27, 2026.</footnote>
        <footnote id="F14">Directly beneficially owned by the Krishnan Family Trust. The reporting person and her spouse are each joint beneficial owners of the trust with joint voting and investment control.</footnote>
        <footnote id="F15">The stock options vest in four equal annual installments beginning on February 27, 2027.</footnote>
        <footnote id="F16">Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date.</footnote>
        <footnote id="F17">The RSUs vest in four equal annual installments with the first installment vesting on February 27, 2027.</footnote>
        <footnote id="F18">Each PSU represents a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the three year performance period, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on the vesting date.</footnote>
        <footnote id="F19">The number of PSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming achievement of all of the performance criteria set by the Company's Compensation Committee for this PSU award and full vesting of this PSU award.</footnote>
        <footnote id="F20">If any applicable portion of the performance criteria have been achieved, the PSU award shall  cliff vest on February 27, 2029.</footnote>
        <footnote id="F21">If some or all of the performance criteria are not achieved, the applicable portion of the PSU award will be forfeited.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Suma M. Krishnan</signatureName>
        <signatureDate>2026-03-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
