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Note 2 - Fair Value of Financial Instruments - Cash and Cash Equivalents (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Cash and cash equivalents | $ 137,328 | $ 74,132
Short-term marketable securities, amortization cost | 268,027 | 281,346
Unrealized gains, short-term securities | 103 | 557
Short-term marketable securities, unrealized loss | (170) | (11)
Short-term marketable securities | 267,960 | 281,892
Long-term marketable securities, amortization cost | 111,374 | 97,414
Unrealized gains, long-term securities | 178 | 1,047
Long-term marketable securities, unrealized loss | (354) | (3)
Long-term marketable securities | 111,198 | 98,458
Cash and cash equivalents and marketable securities, amortization cost | 516,729 | 452,892
Unrealized gains, securities | 281 | 1,604
Unrealized loss, securities | (524) | (14)
Cash and cash equivalents and short-term and long-term Marketable Securities, fair value | 516,486 | 454,482
Commercial Paper, Not Included with Cash and Cash Equivalents [Member] |  |
Short-term marketable securities, amortization cost | 28,869 | 6,147
Unrealized gains, short-term securities | 101 | 0
Short-term marketable securities, unrealized loss | (7) | 0
Short-term marketable securities | 28,963 | 6,147
Corporate Debt Securities [Member] |  |
Short-term marketable securities, amortization cost | 3,952 | 24,368
Unrealized gains, short-term securities | 0 | 170
Short-term marketable securities, unrealized loss | 0 | 0
Short-term marketable securities | 3,952 | 24,538
Long-term marketable securities, amortization cost | 57,762 | 51,068
Unrealized gains, long-term securities | 160 | 839
Long-term marketable securities, unrealized loss | (182) | 0
Long-term marketable securities | 57,740 | 51,907
Asset-backed Securities [Member] |  |
Short-term marketable securities, amortization cost | 217,160 | 6,263
Unrealized gains, short-term securities | 2 | 18
Short-term marketable securities, unrealized loss | (163) | 0
Short-term marketable securities | 216,999 | 6,281
Long-term marketable securities, amortization cost | 14,941 | 38,456
Unrealized gains, long-term securities | 6 | 160
Long-term marketable securities, unrealized loss | (36) | (3)
Long-term marketable securities | 14,911 | 38,613
US Government Agencies Debt Securities [Member] |  |
Short-term marketable securities, amortization cost | 18,046 | 244,568
Unrealized gains, short-term securities | 0 | 369
Short-term marketable securities, unrealized loss | 0 | (11)
Short-term marketable securities | 18,046 | 244,926
Long-term marketable securities, amortization cost | 37,664 | 6,884
Unrealized gains, long-term securities | 0 | 17
Long-term marketable securities, unrealized loss | (136) | 0
Long-term marketable securities | 37,528 | 6,901
Foreign Government Agencies [Member] |  |
Long-term marketable securities, amortization cost | 1,007 | 1,006
Unrealized gains, long-term securities | 12 | 31
Long-term marketable securities, unrealized loss | 0 | 0
Long-term marketable securities | 1,019 | 1,037
Cash [Member] |  |
Cash and cash equivalents | 61,220 | 33,105
Money Market Funds [Member] |  |
Cash and cash equivalents | 75,258 | 38,028
Commercial Paper [Member] |  |
Cash and cash equivalents | $ 850 | $ 2,999

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