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Stock option plan (Tables) | 12 Months Ended
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Dec. 31, 2014
Stock award plan |
Summary of stock option activity |
|  | Number of options |  | Exercise price |  | Weighted- average exercise price |  | Weighted- average remaining contractual term |  | Aggregate intrinsic value |
|  |  |  |  |  |  |  |  |  | (in thousands) |
Outstanding at December 31, 2011 |  |  | 46,794 |  | $226.80 - $1,149.60 |  | $ | 532.80 |  |  | 5.74 years |  |  |  |
Granted |  |  | 5,715 |  | $218.40 |  | $ | 218.40 |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  |  |  |  |  |  |  |  |  |
Forfeited |  |  | (10,115 | ) | $218.40 - $1,149.60 |  | $ | 604.80 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2012 |  |  | 42,394 |  | $218.40 - $1,149.60 |  | $ | 474.00 |  |  | 5.02 years |  |  |  |
Granted |  |  | 2,117,113 |  | $10.59 - $20.76 |  | $ | 11.29 |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  |  |  |  |  |  |  |  |  |
Forfeited |  |  | (63,915 | ) | $10.85 - $1,149.60 |  | $ | 12.57 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2013 |  |  | 2,095,592 |  | $10.59 - $1,149.60 |  | $ | 20.24 |  |  | 9.29 years |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Granted |  |  | 1,639,996 |  | $18.78 - $50.45 |  | $ | 31.09 |  |  |  |  |  |  |
Exercised |  |  | (108,645 | ) | $10.85 - $20.71 |  | $ | 11.00 |  |  |  |  |  |  |
Forfeited |  |  | (193,971 | ) | $10.85 - $1,149.60 |  | $ | 32.91 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2014 |  |  | 3,432,972 |  | $10.59 - $1,149.60 |  | $ | 25.00 |  |  | 8.77 years |  | $ | 106,796 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Vested or expected to vest at December 31, 2014 |  |  | 3,239,515 |  |  |  | $ | 24.15 |  |  | 8.78 years |  | $ | 101,391 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Exercisable at December 31, 2014 |  |  | 764,277 |  |  |  | $ | 31.84 |  |  | 8.24 years |  | $ | 29,809 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Schedule of assumptions used to estimate fair value of grants made on the date of grant |
|  | 2014 |  | 2013 |  | 2012
Risk-free interest rate |  | 0.11 - 2.04% |  | 0.85 - 1.90% |  | 1.14%
Expected volatility |  | 70 - 91% |  | 87 - 89% |  | 87%
Expected term |  | 5.50 - 6.25 years |  | 6.00 - 6.25 years |  | 6.00 - 6.25 years
Summary of stock options outstanding and exercisable | The following table summarizes stock options outstanding and exercisable at December 31, 2014:
|  | Outstanding |  | Exercisable |
Range of Exercise Price |  | Number of Options |  | Weighted- Average Exercise Price |  | Weighted-Average Remaining Contractual Life (in years) |  | Number of Options |  | Weighted Average Exercise Price |
$10.59 - $10.85 |  |  | 1,752,630 |  | $ | 10.85 |  |  | 8.37 |  |  | 704,958 |  | $ | 10.85 |
$10.85 - $20.76 |  |  | 114,425 |  | $ | 19.42 |  |  | 8.90 |  |  | 28,675 |  | $ | 19.72 |
$20.76 - $27.05 |  |  | 982,796 |  | $ | 26.91 |  |  | 9.12 |  |  | 350 |  | $ | 27.05 |
$27.05 - $50.45 |  |  | 554,400 |  | $ | 39.25 |  |  | 9.62 |  |  | 2,968 |  | $ | 40.45 |
$50.45 - $1,149.60 |  |  | 28,721 |  | $ | 569.97 |  |  | 4.32 |  |  | 27,326 |  | $ | 585.05 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
|  |  | 3,432,972 |  |  |  |  |  |  |  |  | 764,277 |  |  |  |
Summary of information on the Company's restricted stock |
|  | Restricted Stock |
|  | Number of Shares |  | Weighted Average Grant Date Fair Value |
January 1, 2014 |  |  | 1,110,226 |  | $ | 10.68 |
Granted |  |  | — |  |  | — |
Vested |  |  | (373,200 | ) | $ | 10.59 |
Forfeited |  |  | (18,626 | ) | $ | 10.75 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Unvested at December 31, 2014 |  |  | 718,400 |  | $ | 10.72 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Schedule of share-based compensation expense recorded in the statement of operations |
|  | Year ended December 31, |
|  | 2014 |  | 2013 |  | 2012 |
Research and development |  | $ | 9,739 |  | $ | 4,312 |  | $ | 1,269 |
Selling, general and administrative |  |  | 9,571 |  |  | 4,115 |  |  | 1,020 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 19,310 |  | $ | 8,427 |  | $ | 2,289 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​

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