XML 45 R32.htm IDEA: XBRL DOCUMENT v2.4.1.9

Stock option plan (Tables)

12 Months Ended

Dec. 31, 2014

Stock award plan

Summary of stock option activity

Number of options

Exercise price

Weighted- average exercise price

Weighted- average remaining contractual term

Aggregate intrinsic value

(in thousands)

Outstanding at December 31, 2011

46,794

$226.80 - $1,149.60

$

532.80

5.74 years

Granted

5,715

$218.40

$

218.40

Exercised

—

Forfeited

(10,115

)

$218.40 - $1,149.60

$

604.80

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Outstanding at December 31, 2012

42,394

$218.40 - $1,149.60

$

474.00

5.02 years

Granted

2,117,113

$10.59 - $20.76

$

11.29

Exercised

—

Forfeited

(63,915

)

$10.85 - $1,149.60

$

12.57

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Outstanding at December 31, 2013

2,095,592

$10.59 - $1,149.60

$

20.24

9.29 years

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Granted

1,639,996

$18.78 - $50.45

$

31.09

Exercised

(108,645

)

$10.85 - $20.71

$

11.00

Forfeited

(193,971

)

$10.85 - $1,149.60

$

32.91

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Outstanding at December 31, 2014

3,432,972

$10.59 - $1,149.60

$

25.00

8.77 years

$

106,796

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Vested or expected to vest at December 31, 2014

3,239,515

$

24.15

8.78 years

$

101,391

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Exercisable at December 31, 2014

764,277

$

31.84

8.24 years

$

29,809

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Schedule of assumptions used to estimate fair value of grants made on the date of grant

		2014		2013		2012
Risk-free interest rate		0.11 - 2.04%		0.85 - 1.90%		1.14%
Expected volatility		70 - 91%		87 - 89%		87%
Expected term		5.50 - 6.25 years		6.00 - 6.25 years		6.00 - 6.25 years

Summary of stock options outstanding and exercisable

          The following table summarizes stock options outstanding and exercisable at December 31, 2014:

		Outstanding									Exercisable
Range of Exercise Price		Number of Options			Weighted- Average Exercise Price			Weighted-Average Remaining Contractual Life (in years)			Number of Options			Weighted Average Exercise Price
$10.59 - $10.85			1,752,630		$	10.85			8.37			704,958		$	10.85
$10.85 - $20.76			114,425		$	19.42			8.90			28,675		$	19.72
$20.76 - $27.05			982,796		$	26.91			9.12			350		$	27.05
$27.05 - $50.45			554,400		$	39.25			9.62			2,968		$	40.45
$50.45 - $1,149.60			28,721		$	569.97			4.32			27,326		$	585.05
​	​	​	​	​	​	​	​	​	​	​	​	​	​	​	​	​
			3,432,972									764,277

Summary of information on the Company's restricted stock

		Restricted Stock
		Number of Shares			Weighted Average Grant Date Fair Value
January 1, 2014			1,110,226		$	10.68
Granted			—			—
Vested			(373,200	)	$	10.59
Forfeited			(18,626	)	$	10.75
​	​	​	​	​	​	​	​
Unvested at December 31, 2014			718,400		$	10.72
​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​

Schedule of share-based compensation expense recorded in the statement of operations

		Year ended December 31,
		2014			2013			2012
Research and development		$	9,739		$	4,312		$	1,269
Selling, general and administrative			9,571			4,115			1,020
​	​	​	​	​	​	​	​	​	​	​
Total		$	19,310		$	8,427		$	2,289
​	​	​	​	​	​	​	​	​	​	​

X

- Details

Name:	us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (c)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_NonvestedRestrictedStockSharesActivityTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 1

-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901



Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SAB TOPIC 14.F)

-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809



Reference 3: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Staff Accounting Bulletin (SAB)

-Number Topic 14

-Section F



Reference 4: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (h)(1)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of option exercise prices, by grouped ranges, including the upper and lower limits of the price range, the number of shares under option, weighted average exercise price and remaining contractual option terms.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (c)(1)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (f)(2)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration