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Number of shares issuable for each share of convertible preferred stock.

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Represents the cash inflow from issuance of convertible preferred stock and borrowings having initial term of repayment within one year or the normal operating cycle, if longer.

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The cash inflow associated with the amount received from the entity's public offering of stock.

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Amount of noncash expense included in interest expense to amortize debt discount and premium associated with the related debt instruments. Excludes amortization of financing costs. Alternate captions include noncash interest expense.

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Exercise price per share or per unit of warrants or rights outstanding.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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The maximum number of common shares permitted to be issued by an entity's charter and bylaws.

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Number of shares issued for each share of convertible preferred stock that is converted.

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The number of shares issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period.

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Face (par) amount of debt instrument at time of issuance.

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The excess of (1) the carrying amount of the preferred stock in the registrant's balance sheet over (2) the fair value of the consideration transferred to the holders of the preferred stock, during the accounting period, which will be added to net earnings to arrive at net earnings available to common shareholders in the calculation of earnings per share.

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The cash inflow associated with the amount received from entity's first offering of stock to the public.

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The cash inflow from issuance of preferred stocks identified as being convertible into another form of financial instrument, typically the entity's common stock.

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The cash inflow from a borrowing having initial term of repayment within one year or the normal operating cycle, if longer.

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Price of a single share of a number of saleable stocks of a company.

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Amount per share or per unit of equity securities issued by non-development stage entity.

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Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

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Number of new stock issued during the period.

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Equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.

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Capital structure (Details 2) (USD $)	1 Months Ended	3 Months Ended		12 Months Ended			0 Months Ended	1 Months Ended	0 Months Ended	1 Months Ended
Capital structure (Details 2) (USD $)	Jul. 31, 2012	Mar. 31, 2014	Mar. 31, 2013	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012	Mar. 07, 2013	May 31, 2013	Oct. 16, 2014	Feb. 28, 2014	Jun. 30, 2013	Feb. 28, 2013
Capital structure
Aggregate gross proceeds						$ 29,355,000
Gross proceeds raised		60,000,000
Gain on extinguishment of shares of Series One, Two and Three stock	160,000,000		3,391,000		3,391,000	159,954,000
Aggregate purchase price				235,979,097	131,649,688
Common stock
Common stock, authorized shares				125,000,000us-gaap_CommonStockSharesAuthorized	125,000,000us-gaap_CommonStockSharesAuthorized			125,000,000us-gaap_CommonStockSharesAuthorized
Series One and Series Two \| Warrant
Capital structure
Warrants issued to purchase shares												2,527,675
Exercise price (in dollars per share)												$ 0.01
Shares issued and sold							2,527,675
Series Four convertible preferred stock
Capital structure
Shares issued and sold							4,497,035	375,000
Aggregate gross proceeds							54,000,000
Share price (in dollars per share)								$ 12.00
Aggregate purchase price								4,500,000
Series Five convertible preferred stock
Capital structure
Number of shares issued upon conversion							6,700,487
Common stock
Number of shares issued upon conversion							6,700,487
Series Five convertible preferred stock \| Warrant
Capital structure
Number of shares issued upon conversion							2,095,515
Common stock
Number of shares issued upon conversion							2,095,515
Common stock
Capital structure
Shares issued and sold									3,450,000	5,163,265	9,627,800
Reverse stock split ratio							0.0083
Share price (in dollars per share)											$ 15.00
Public offering price (in dollars per share)									$ 36.25	$ 24.50
Common stock
Common stock shares issuable pursuant to the exercise by the underwriters of an over-allotment option									450,000	673,469	1,255,800
Net proceeds from public offerings									117,600,000	118,400,000
Net proceeds from initial public offering											131,600,000
Series Four and Series Five Convertible Preferred Stock
Capital structure
Number of shares issued upon conversion											14,170,956
Number of shares issuable upon conversion of each stock											1
Common stock
Number of shares issued upon conversion											14,170,956
Convertible promissory notes
Capital structure
Principal amount of convertible promissory notes issued												6,000,000
Debt discount recorded to interest expense		6,000,000
Amount raised in bridge financing		$ 6,000,000
Convertible promissory notes \| Series Four convertible preferred stock
Capital structure
Shares issued upon conversion of convertible promissory notes							502,919