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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Cash flows from operating activities      
Net loss $ (93,753)us-gaap_NetIncomeLoss $ (51,574)us-gaap_NetIncomeLoss $ (26,235)us-gaap_NetIncomeLoss
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 2,235us-gaap_Depreciation 2,396us-gaap_Depreciation 2,704us-gaap_Depreciation
Change in valuation of warrant liability 130us-gaap_FairValueAdjustmentOfWarrants (38)us-gaap_FairValueAdjustmentOfWarrants (1,783)us-gaap_FairValueAdjustmentOfWarrants
Non-cash interest expense   6,049us-gaap_PaidInKindInterest 226us-gaap_PaidInKindInterest
Loss on extinguishment of debt   130us-gaap_GainsLossesOnExtinguishmentOfDebt  
Share-based compensation expense 19,310us-gaap_ShareBasedCompensation 8,427us-gaap_ShareBasedCompensation 2,289us-gaap_ShareBasedCompensation
Amortization of premiums on investments 1,607us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments    
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets (2,286)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets (760)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets 2,452us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
Receivables, net (3,487)us-gaap_IncreaseDecreaseInReceivables 56us-gaap_IncreaseDecreaseInReceivables 230us-gaap_IncreaseDecreaseInReceivables
Deposits and other assets (340)us-gaap_IncreaseDecreaseInDepositOtherAssets 48us-gaap_IncreaseDecreaseInDepositOtherAssets 84us-gaap_IncreaseDecreaseInDepositOtherAssets
Accounts payable and accrued expenses 16,914us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities 5,183us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities (6,026)us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
Other long-term liabilities (80)us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities (285)us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities 103us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities
Deferred revenue 2,476us-gaap_IncreaseDecreaseInDeferredRevenue (16,554)us-gaap_IncreaseDecreaseInDeferredRevenue (21,972)us-gaap_IncreaseDecreaseInDeferredRevenue
Net cash used in operating activities (57,274)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (46,922)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (47,928)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
Cash flows from investing activities      
Purchases of fixed assets (4,664)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (846)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (189)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Purchases of marketable securities (247,804)us-gaap_PaymentsToAcquireMarketableSecurities (156,045)us-gaap_PaymentsToAcquireMarketableSecurities  
Sale & redemption of marketable securities 107,300us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities 29,062us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities  
Net cash used in investing activities (145,168)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (127,829)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (189)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities      
Payments on long-term debt (49)us-gaap_RepaymentsOfLongTermDebt (4,996)us-gaap_RepaymentsOfLongTermDebt (6,944)us-gaap_RepaymentsOfLongTermDebt
Net proceeds from sale of Series One preferred stock     29,355us-gaap_ProceedsFromIssuanceOfConvertiblePreferredStock
Net proceeds from sale of Series Four convertible preferred stock   60,785us-gaap_SaleOfStockConsiderationReceivedOnTransaction  
Net proceeds from public offerings 235,979us-gaap_ProceedsFromIssuanceOfCommonStock 131,650us-gaap_ProceedsFromIssuanceOfCommonStock  
Proceeds from exercise of options 1,196us-gaap_ProceedsFromStockOptionsExercised    
Net cash provided by financing activities 237,126us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 187,439us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 22,411us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
Effect of exchange rate changes on cash (350)us-gaap_EffectOfExchangeRateOnCash    
Net increase (decrease) in cash and cash equivalents 34,334us-gaap_NetCashProvidedByUsedInContinuingOperations 12,688us-gaap_NetCashProvidedByUsedInContinuingOperations (25,706)us-gaap_NetCashProvidedByUsedInContinuingOperations
Cash and cash equivalents, beginning of period 15,414us-gaap_CashAndCashEquivalentsAtCarryingValue 2,726us-gaap_CashAndCashEquivalentsAtCarryingValue 28,432us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents, end of period 49,748us-gaap_CashAndCashEquivalentsAtCarryingValue 15,414us-gaap_CashAndCashEquivalentsAtCarryingValue 2,726us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosure of cash information      
Cash paid for interest 1us-gaap_InterestPaid 367us-gaap_InterestPaid 1,212us-gaap_InterestPaid
Cash paid for income taxes   2us-gaap_IncomeTaxesPaidNet 2us-gaap_IncomeTaxesPaidNet
Supplemental disclosures of non-cash information related to investing and financing activities      
Change in unrealized gain (loss) on marketable securities (457)ptct_ChangeInUnrealizedGainLossOnMarketableSecurities 70ptct_ChangeInUnrealizedGainLossOnMarketableSecurities  
Change in carry value of preferred securities resulting from recapitalization   $ 3,391ptct_ChangeInCarryingValueOfPreferredSecuritiesResultingFromRecapitalization $ 159,954ptct_ChangeInCarryingValueOfPreferredSecuritiesResultingFromRecapitalization