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Stock award plan (Tables) | 3 Months Ended
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Mar. 31, 2015
Stock award plan |
Summary of stock option activity |
|  | Number of options |  | Weighted- average exercise price |  | Weighted- average remaining contractual term |  | Aggregate intrinsic value |
|  |  |  |  |  |  |  | (in thousands) |
Outstanding at December 31, 2014 |  | 3,432,972 |  | $ | 25.00 |  |  |  |  |
Granted |  | 1,456,550 |  | $ | 51.02 |  |  |  |  |
Exercised |  | (234,830 | ) | $ | 12.86 |  |  |  |  |
Forfeited |  | (26,265 | ) | $ | 47.52 |  |  |  |  |
Expired |  | (594 | ) | $ | 388.53 |  |  |  |  |
Outstanding at March 31, 2015 |  | 4,627,833 |  | $ | 33.60 |  | 8.9 years |  | $ | 140,399 |
Vested or Expected to vest at March 31, 2015 |  | 4,332,726 |  | $ | 32.74 |  | 8.9 years |  | $ | 133,232 |
Exercisable at March 31, 2015 |  | 1,037,262 |  | $ | 30.98 |  | 8.2 years |  | $ | 45,137 |
Schedule of assumptions used to estimate fair value of grants made on the date of grant |
|  | Three months ended March 31, 2015 |
Risk-free interest rate |  | 1.54% — 1.77% |
Expected volatility |  | 67%-69% |
Expected term |  | 5.50 - 6.11 years |
Summary of information on the Company's restricted stock |
|  | Restricted Stock |
|  | Number of Shares |  | Weighted Average Grant Date Fair Value |
January 1, 2015 |  | 718,400 |  | $ | 10.72 |
Granted |  | — |  | — |
Vested |  | (350,084 | ) | $ | 10.59 |
Forfeited |  | (3,346 | ) | $ | 10.82 |
Unvested at March 31, 2015 |  | 364,970 |  | $ | 10.85 |
Schedule of share-based compensation expense recorded in the statement of operations |
|  | Three Months Ended March 31, |
|  | 2015 |  | 2014 |
Research and development |  | $ | 4,667 |  | $ | 1,944 |
Selling, general and administrative |  | 5,081 |  | 1,761 |
Total |  | $ | 9,748 |  | $ | 3,705 |

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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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