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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Cash flows from operating activities    
Net loss $ (76,276) $ (39,202)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 1,319 1,150
Change in valuation of warrant liability (72) 38
Amortization of premiums on investments 915 910
Share-based compensation expense 18,076 7,983
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (356) (998)
Receivables, net (669) 100
Deposits and other assets 258 (678)
Accounts payable and accrued expenses (6,039) (866)
Other long-term liabilities (46) (46)
Deferred revenue (3,354) (636)
Net cash used in operating activities (66,244) (32,245)
Cash flows from investing activities    
Purchases of fixed assets (1,177) (837)
Purchases of marketable securities (44,988) (132,603)
Sale and redemption of marketable securities 83,468 53,079
Net cash provided by/(used in) investing activities 37,303 (80,361)
Cash flows from financing activities    
Payments on long-term debt   (49)
Proceeds from exercise of options 8,072 30
Net proceeds from public offerings   118,383
Net cash provided by financing activities 8,072 118,364
Effect of exchange rate changes on cash 341  
Net (decrease)/increase in cash and cash equivalents (20,528) 5,758
Cash and cash equivalents, beginning of period 49,748 15,414
Cash and cash equivalents, end of period 29,220 21,172
Supplemental disclosure of cash information    
Cash paid for interest   1
Supplemental disclosures of non-cash information related to investing and financing activities    
Change in unrealized (loss) gain on marketable securities $ (99) $ 20