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The Company (Details)
$ in Thousands
1 Months Ended 9 Months Ended
Aug. 04, 2014
Aug. 31, 2014
state
Sep. 30, 2015
USD ($)
Aug. 31, 2015
Dec. 31, 2014
USD ($)
Minimum age of ambulatory patient 5 years 5 years      
Number of member states of the European Economic Area   31      
Period of market access for launching new product     18 months    
Accumulated deficit | $     $ (542,050)   $ (422,551)
Convertible debt | 3.0% Convertible senior notes due 2022          
Interest rate       3.00%